Antioxidant and Antifibrotic Effect of a Herbal Formulation In Vitro and in the Experimental Andropause via Nrf2HO-1 Signaling Pathway
Joint Authors
Ha, U-Syn
Lee, Ji Youl
Hwang, Sung Yeoun
Koo, Hye Cheong
Kim, Kang Sup
Kim, Su Jin
Kim, Sae Woong
Hong, Sung Hoo
Bae, Woong Jin
Kim, Do Ram
Zhu, Guan Qun
Choi, Sae Woong
Jeong, Hyun Cheol
Bashraheel, Fahad
Cho, Hyuk Jin
Oh, Hyun-A
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-17
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The Korean herbal formulation Ojayeonjonghwan is used for improving late-onset hypogonadism (LOH) symptoms such as erectile dysfunction (ED).
A previous research suggested that a modified Ojayeonjonghwan (KH-204) could be used as an alternative to the treatment for ED.
The pharmacological effects were examined in different conditions, including in vitro and in vivo.
We measured the survival rate of TM3 Leydig cells under the oxidative stress condition.
The s.c.
injection of leuprorelin was used to induce androgen deprivation.
We measured serum testosterone levels, oxidative stress, and apoptosis.
The results of the treatment by KH-204 (1) preserved TM3 cells from oxidative stress by improving the expression of nuclear factor erythroid 2-related factor 2 (Nrf2)/heme oxygenase-1 (HO-1); (2) lowered the expression of transforming growth factor-beta (TGF-β) 1/SMAD; (3) increased the average of serum testosterone in androgen-deprived male rats; (4) kept the activation of spermatogenesis; (5) upgraded the contents of 8-hydroxy-20-deoxyguanosine (8-OHdG) and degraded the contents of superoxide dismutase (SOD); and (6) reduced apoptosis.
We studied that KH-204 improved testicular dysfunction in LOH.
It is likely, at least in part, to degrade oxidative stress through the Nrf2/HO-1 pathway.
These findings may offer credible evidences for the use of new alternative therapies to treat LOH.
American Psychological Association (APA)
Bae, Woong Jin& Zhu, Guan Qun& Choi, Sae Woong& Jeong, Hyun Cheol& Bashraheel, Fahad& Kim, Kang Sup…[et al.]. 2017. Antioxidant and Antifibrotic Effect of a Herbal Formulation In Vitro and in the Experimental Andropause via Nrf2HO-1 Signaling Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1195119
Modern Language Association (MLA)
Bae, Woong Jin…[et al.]. Antioxidant and Antifibrotic Effect of a Herbal Formulation In Vitro and in the Experimental Andropause via Nrf2HO-1 Signaling Pathway. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1195119
American Medical Association (AMA)
Bae, Woong Jin& Zhu, Guan Qun& Choi, Sae Woong& Jeong, Hyun Cheol& Bashraheel, Fahad& Kim, Kang Sup…[et al.]. Antioxidant and Antifibrotic Effect of a Herbal Formulation In Vitro and in the Experimental Andropause via Nrf2HO-1 Signaling Pathway. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1195119
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195119