The eIF4E2-Directed Hypoxic Cap-Dependent Translation Machinery Reveals Novel Therapeutic Potential for Cancer Treatment
Joint Authors
Melanson, Gaelan
Timpano, Sara
Uniacke, James
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-26
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Hypoxia is an aspect of the tumor microenvironment that is linked to radiation and chemotherapy resistance, metastasis, and poor prognosis.
The ability of hypoxic tumor cells to achieve these cancer hallmarks is, in part, due to changes in their gene expression profiles.
Cancer cells have a high demand for protein synthesis, and translational control is subsequently deregulated.
Various mechanisms of translation initiation are active to improve the translation efficiency of select transcripts to drive cancer progression.
This review will focus on a noncanonical cap-dependent translation initiation mechanism that utilizes the eIF4E homolog eIF4E2, a hypoxia-activated cap-binding protein that is implicated in hypoxic cancer cell migration, invasion, and tumor growth in mouse xenografts.
A historical perspective about eIF4E2 and its various aliases will be provided followed by an evaluation of potential therapeutic strategies.
The recent successes of disabling canonical translation and eIF4E with drugs should highlight the novel therapeutic potential of targeting the homologous eIF4E2 in the treatment of hypoxic solid tumors.
American Psychological Association (APA)
Melanson, Gaelan& Timpano, Sara& Uniacke, James. 2017. The eIF4E2-Directed Hypoxic Cap-Dependent Translation Machinery Reveals Novel Therapeutic Potential for Cancer Treatment. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1195164
Modern Language Association (MLA)
Melanson, Gaelan…[et al.]. The eIF4E2-Directed Hypoxic Cap-Dependent Translation Machinery Reveals Novel Therapeutic Potential for Cancer Treatment. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1195164
American Medical Association (AMA)
Melanson, Gaelan& Timpano, Sara& Uniacke, James. The eIF4E2-Directed Hypoxic Cap-Dependent Translation Machinery Reveals Novel Therapeutic Potential for Cancer Treatment. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1195164
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195164