Insights for Oxidative Stress and mTOR Signaling in Myocardial IschemiaReperfusion Injury under Diabetes
Joint Authors
Zhao, Dajun
Yang, Jian
Yang, Lifang
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Diabetes mellitus (DM) displays a high morbidity.
The diabetic heart is susceptible to myocardial ischemia/reperfusion (MI/R) injury.
Impaired activation of prosurvival pathways, endoplasmic reticulum (ER) stress, increased basal oxidative state, and decreased antioxidant defense and autophagy may render diabetic hearts more vulnerable to MI/R injury.
Oxidative stress and mTOR signaling crucially regulate cardiometabolism, affecting MI/R injury under diabetes.
Producing reactive oxygen species (ROS) and reactive nitrogen species (RNS), uncoupling nitric oxide synthase (NOS), and disturbing the mitochondrial quality control may be three major mechanisms of oxidative stress.
mTOR signaling presents both cardioprotective and cardiotoxic effects on the diabetic heart, which interplays with oxidative stress directly or indirectly.
Antihyperglycemic agent metformin and newly found free radicals scavengers, Sirt1 and CTRP9, may serve as promising pharmacological therapeutic targets.
In this review, we will focus on the role of oxidative stress and mTOR signaling in the pathophysiology of MI/R injury in diabetes and discuss potential mechanisms and their interactions in an effort to provide some evidence for cardiometabolic targeted therapies for ischemic heart disease (IHD).
American Psychological Association (APA)
Zhao, Dajun& Yang, Jian& Yang, Lifang. 2017. Insights for Oxidative Stress and mTOR Signaling in Myocardial IschemiaReperfusion Injury under Diabetes. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1195244
Modern Language Association (MLA)
Zhao, Dajun…[et al.]. Insights for Oxidative Stress and mTOR Signaling in Myocardial IschemiaReperfusion Injury under Diabetes. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1195244
American Medical Association (AMA)
Zhao, Dajun& Yang, Jian& Yang, Lifang. Insights for Oxidative Stress and mTOR Signaling in Myocardial IschemiaReperfusion Injury under Diabetes. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1195244
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195244