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Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans
Joint Authors
Peluso, Ilaria
Marrocco, Ilaria
Altieri, Fabio
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-32, 32 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-18
Country of Publication
Egypt
No. of Pages
32
Main Subjects
Abstract EN
Oxidative stress is the result of the imbalance between reactive oxygen species (ROS) formation and enzymatic and nonenzymatic antioxidants.
Biomarkers of oxidative stress are relevant in the evaluation of the disease status and of the health-enhancing effects of antioxidants.
We aim to discuss the major methodological bias of methods used for the evaluation of oxidative stress in humans.
There is a lack of consensus concerning the validation, standardization, and reproducibility of methods for the measurement of the following: (1) ROS in leukocytes and platelets by flow cytometry, (2) markers based on ROS-induced modifications of lipids, DNA, and proteins, (3) enzymatic players of redox status, and (4) total antioxidant capacity of human body fluids.
It has been suggested that the bias of each method could be overcome by using indexes of oxidative stress that include more than one marker.
However, the choice of the markers considered in the global index should be dictated by the aim of the study and its design, as well as by the clinical relevance in the selected subjects.
In conclusion, the clinical significance of biomarkers of oxidative stress in humans must come from a critical analysis of the markers that should give an overall index of redox status in particular conditions.
American Psychological Association (APA)
Marrocco, Ilaria& Altieri, Fabio& Peluso, Ilaria. 2017. Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-32.
https://search.emarefa.net/detail/BIM-1195254
Modern Language Association (MLA)
Marrocco, Ilaria…[et al.]. Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-32.
https://search.emarefa.net/detail/BIM-1195254
American Medical Association (AMA)
Marrocco, Ilaria& Altieri, Fabio& Peluso, Ilaria. Measurement and Clinical Significance of Biomarkers of Oxidative Stress in Humans. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-32.
https://search.emarefa.net/detail/BIM-1195254
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195254