Lung-Protective Ventilation Strategies for Relief from Ventilator-Associated Lung Injury in Patients Undergoing Craniotomy: A Bicenter Randomized, Parallel, and Controlled Trial
Joint Authors
Zhao, Bo
Tang, Chaoliang
Li, Juan
Zhang, Zhetao
Huang, Wenting
Shi, Si
Chai, Xiaoqing
Niu, Chaoshi
Lei, Shao-Qing
Xia, Zhong-Yuan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Current evidence indicates that conventional mechanical ventilation often leads to lung inflammatory response and oxidative stress, while lung-protective ventilation (LPV) minimizes the risk of ventilator-associated lung injury (VALI).
This study evaluated the effects of LPV on relief of pulmonary injury, inflammatory response, and oxidative stress among patients undergoing craniotomy.
Sixty patients undergoing craniotomy received either conventional mechanical (12 mL/kg tidal volume [VT] and 0 cm H2O positive end-expiratory pressure [PEEP]; CV group) or protective lung (6 mL/kg VT and 10 cm H2O PEEP; PV group) ventilation.
Hemodynamic variables, lung function indexes, and inflammatory and oxidative stress markers were assessed.
The PV group exhibited greater dynamic lung compliance and lower respiratory index than the CV group during surgery (P<0.05).
The PV group exhibited higher plasma interleukin- (IL-) 10 levels and lower plasma malondialdehyde and nitric oxide and bronchoalveolar lavage fluid, IL-6, IL-8, tumor necrosis factor-α, IL-10, malondialdehyde, nitric oxide, and superoxide dismutase levels (P<0.05) than the CV group.
There were no significant differences in hemodynamic variables, blood loss, liquid input, urine output, or duration of mechanical ventilation between the two groups (P>0.05).
Patients receiving LPV during craniotomy exhibited low perioperative inflammatory response, oxidative stress, and VALI.
American Psychological Association (APA)
Tang, Chaoliang& Li, Juan& Lei, Shao-Qing& Zhao, Bo& Zhang, Zhetao& Huang, Wenting…[et al.]. 2017. Lung-Protective Ventilation Strategies for Relief from Ventilator-Associated Lung Injury in Patients Undergoing Craniotomy: A Bicenter Randomized, Parallel, and Controlled Trial. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1195257
Modern Language Association (MLA)
Tang, Chaoliang…[et al.]. Lung-Protective Ventilation Strategies for Relief from Ventilator-Associated Lung Injury in Patients Undergoing Craniotomy: A Bicenter Randomized, Parallel, and Controlled Trial. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1195257
American Medical Association (AMA)
Tang, Chaoliang& Li, Juan& Lei, Shao-Qing& Zhao, Bo& Zhang, Zhetao& Huang, Wenting…[et al.]. Lung-Protective Ventilation Strategies for Relief from Ventilator-Associated Lung Injury in Patients Undergoing Craniotomy: A Bicenter Randomized, Parallel, and Controlled Trial. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1195257
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195257