Exercise Inhibits the Effects of Smoke-Induced COPD Involving Modulation of STAT3

Joint Authors

Vieira, Rodolfo P.
Oliveira-Junior, Manoel Carneiro
Choqueta de Toledo-Arruda, Alessandra
Brito, Auriléia Aparecida de
Ligeiro de Oliveira, Ana Paula
Rodrigues Brandao-Rangel, Maysa Alves
Bachi, Andre Luis Lacerda
Abbasi, Asghar
Silva-Renno, Adriano
Belvisi, Maria Gabriela

Source

Oxidative Medicine and Cellular Longevity

Issue

Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2017-10-18

Country of Publication

Egypt

No. of Pages

13

Main Subjects

Biology

Abstract EN

Purpose.

Evaluate the participation of STAT3 in the effects of aerobic exercise (AE) in a model of smoke-induced COPD.

Methods.

C57Bl/6 male mice were divided into control, Exe, COPD, and COPD+Exe groups.

Smoke were administered during 90 days.

Treadmill aerobic training begun on day 61 until day 90.

Pulmonary inflammation, systemic inflammation, the level of lung emphysema, and the airway remodeling were evaluated.

Analysis of integral and phosphorylated expression of STAT3 by airway epithelial cells, peribronchial leukocytes, and parenchymal leukocytes was performed.

Results.

AE inhibited smoke-induced accumulation of total cells (p<0.001), lymphocytes (p<0.001), and neutrophils (p<0.001) in BAL, as well as BAL levels of IL-1β (p<0.001), CXCL1 (p<0.001), IL-17 (p<0.001), and TNF-α (p<0.05), while increased the levels of IL-10 (p<0.001).

AE also inhibited smoke-induced increases in total leukocytes (p<0.001), neutrophils (p<0.05), lymphocytes (p<0.001), and monocytes (p<0.01) in blood, as well as serum levels of IL-1β (p<0.01), CXCL1 (p<0.01), IL-17 (p<0.05), and TNF-α (p<0.01), while increased the levels of IL-10 (p<0.001).

AE reduced smoke-induced emphysema (p<0.001) and collagen fiber accumulation in the airways (p<0.001).

AE reduced smoke-induced STAT3 and phospho-STAT3 expression in airway epithelial cells (p<0.001), peribronchial leukocytes (p<0.001), and parenchymal leukocytes (p<0.001).

Conclusions.

AE reduces smoke-induced COPD phenotype involving STAT3.

American Psychological Association (APA)

Rodrigues Brandao-Rangel, Maysa Alves& Bachi, Andre Luis Lacerda& Oliveira-Junior, Manoel Carneiro& Abbasi, Asghar& Silva-Renno, Adriano& Brito, Auriléia Aparecida de…[et al.]. 2017. Exercise Inhibits the Effects of Smoke-Induced COPD Involving Modulation of STAT3. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1195267

Modern Language Association (MLA)

Rodrigues Brandao-Rangel, Maysa Alves…[et al.]. Exercise Inhibits the Effects of Smoke-Induced COPD Involving Modulation of STAT3. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1195267

American Medical Association (AMA)

Rodrigues Brandao-Rangel, Maysa Alves& Bachi, Andre Luis Lacerda& Oliveira-Junior, Manoel Carneiro& Abbasi, Asghar& Silva-Renno, Adriano& Brito, Auriléia Aparecida de…[et al.]. Exercise Inhibits the Effects of Smoke-Induced COPD Involving Modulation of STAT3. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1195267

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1195267