Exercise Inhibits the Effects of Smoke-Induced COPD Involving Modulation of STAT3
Joint Authors
Vieira, Rodolfo P.
Oliveira-Junior, Manoel Carneiro
Choqueta de Toledo-Arruda, Alessandra
Brito, Auriléia Aparecida de
Ligeiro de Oliveira, Ana Paula
Rodrigues Brandao-Rangel, Maysa Alves
Bachi, Andre Luis Lacerda
Abbasi, Asghar
Silva-Renno, Adriano
Belvisi, Maria Gabriela
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-18
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Purpose.
Evaluate the participation of STAT3 in the effects of aerobic exercise (AE) in a model of smoke-induced COPD.
Methods.
C57Bl/6 male mice were divided into control, Exe, COPD, and COPD+Exe groups.
Smoke were administered during 90 days.
Treadmill aerobic training begun on day 61 until day 90.
Pulmonary inflammation, systemic inflammation, the level of lung emphysema, and the airway remodeling were evaluated.
Analysis of integral and phosphorylated expression of STAT3 by airway epithelial cells, peribronchial leukocytes, and parenchymal leukocytes was performed.
Results.
AE inhibited smoke-induced accumulation of total cells (p<0.001), lymphocytes (p<0.001), and neutrophils (p<0.001) in BAL, as well as BAL levels of IL-1β (p<0.001), CXCL1 (p<0.001), IL-17 (p<0.001), and TNF-α (p<0.05), while increased the levels of IL-10 (p<0.001).
AE also inhibited smoke-induced increases in total leukocytes (p<0.001), neutrophils (p<0.05), lymphocytes (p<0.001), and monocytes (p<0.01) in blood, as well as serum levels of IL-1β (p<0.01), CXCL1 (p<0.01), IL-17 (p<0.05), and TNF-α (p<0.01), while increased the levels of IL-10 (p<0.001).
AE reduced smoke-induced emphysema (p<0.001) and collagen fiber accumulation in the airways (p<0.001).
AE reduced smoke-induced STAT3 and phospho-STAT3 expression in airway epithelial cells (p<0.001), peribronchial leukocytes (p<0.001), and parenchymal leukocytes (p<0.001).
Conclusions.
AE reduces smoke-induced COPD phenotype involving STAT3.
American Psychological Association (APA)
Rodrigues Brandao-Rangel, Maysa Alves& Bachi, Andre Luis Lacerda& Oliveira-Junior, Manoel Carneiro& Abbasi, Asghar& Silva-Renno, Adriano& Brito, Auriléia Aparecida de…[et al.]. 2017. Exercise Inhibits the Effects of Smoke-Induced COPD Involving Modulation of STAT3. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1195267
Modern Language Association (MLA)
Rodrigues Brandao-Rangel, Maysa Alves…[et al.]. Exercise Inhibits the Effects of Smoke-Induced COPD Involving Modulation of STAT3. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1195267
American Medical Association (AMA)
Rodrigues Brandao-Rangel, Maysa Alves& Bachi, Andre Luis Lacerda& Oliveira-Junior, Manoel Carneiro& Abbasi, Asghar& Silva-Renno, Adriano& Brito, Auriléia Aparecida de…[et al.]. Exercise Inhibits the Effects of Smoke-Induced COPD Involving Modulation of STAT3. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1195267
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195267