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Comparison of Selected Parameters of Redox Homeostasis in Patients with Ataxia-Telangiectasia and Nijmegen Breakage Syndrome
Joint Authors
Maciejczyk, M.
Zalewska, A.
Car, Halina
Pietrucha, Barbara
Heropolitanska-Pliszka, Edyta
Sawicka-Powierza, Jolanta
Motkowski, Radosław
Hryniewicka, Marta
Pac, Malgorzata
Wolska-Kusnierz, Beata
Bernatowska, Ewa
Mikoluc, Bozena
Karpińska, Joanna
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-31
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
This study compared the antioxidant status and major lipophilic antioxidants in patients with ataxia-telangiectasia (AT) and Nijmegen breakage syndrome (NBS).
Total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), and concentrations of coenzyme Q10 (CoQ10) and vitamins A and E were estimated in the plasma of 22 patients with AT, 12 children with NBS, and the healthy controls.
In AT patients, TAS (median 261.7 μmol/L) was statistically lower but TOS (496.8 μmol/L) was significantly elevated in comparison with the healthy group (312.7 μmol/L and 311.2 μmol/L, resp.).
Tocopherol (0.8 μg/mL) and CoQ10 (0.1 μg/mL) were reduced in AT patients versus control (1.4 μg/mL and 0.3 μg/mL, resp.).
NBS patients also displayed statistically lower TAS levels (290.3 μmol/L), while TOS (404.8 μmol/L) was comparable to the controls.
We found that in NBS patients retinol concentration (0.1 μg/mL) was highly elevated and CoQ10 (0.1 μg/mL) was significantly lower in comparison with those in the healthy group.
Our study confirms disturbances in redox homeostasis in AT and NBS patients and indicates a need for diagnosing oxidative stress in those cases as a potential disease biomarker.
Decreased CoQ10 concentration found in NBS and AT indicates a need for possible supplementation.
American Psychological Association (APA)
Pietrucha, Barbara& Heropolitanska-Pliszka, Edyta& Maciejczyk, M.& Car, Halina& Sawicka-Powierza, Jolanta& Motkowski, Radosław…[et al.]. 2017. Comparison of Selected Parameters of Redox Homeostasis in Patients with Ataxia-Telangiectasia and Nijmegen Breakage Syndrome. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1195294
Modern Language Association (MLA)
Pietrucha, Barbara…[et al.]. Comparison of Selected Parameters of Redox Homeostasis in Patients with Ataxia-Telangiectasia and Nijmegen Breakage Syndrome. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1195294
American Medical Association (AMA)
Pietrucha, Barbara& Heropolitanska-Pliszka, Edyta& Maciejczyk, M.& Car, Halina& Sawicka-Powierza, Jolanta& Motkowski, Radosław…[et al.]. Comparison of Selected Parameters of Redox Homeostasis in Patients with Ataxia-Telangiectasia and Nijmegen Breakage Syndrome. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1195294
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195294