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The Repeated Administration of Resveratrol Has Measurable Effects on Circulating T-Cell Subsets in Humans
Joint Authors
Espinoza, J. Luis
Trung, Ly Quoc
Inaoka, Pleiades T.
Yamada, Kayoko
An, Dao T.
Mizuno, Shohei
Nakao, Shinji
Takami, Akiyoshi
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-04
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Preclinical studies have shown that resveratrol exerts immunomodulatory effects with potential clinical value in the amelioration of autoimmune disorders and cancer prevention; however, little is known about the in vivo effects of this naturally occurring polyphenol on human immune cells.
We assessed the effects of repeated doses of resveratrol (1000 mg/day for 28 days) on circulating immune cells in healthy Japanese individuals.
Resveratrol was safe and well tolerated and was associated with significant increases in the numbers of circulating γδ T cells and regulatory T cells and resulted in small, yet significant, decreases in the plasma levels of the proinflammatory cytokines TNF-α and MCP-1 and a significant increase in the plasma antioxidant activity compared with the corresponding antioxidant baseline activity and with that in four control individuals.
In in vitro studies, resveratrol significantly improved the growth of γδ T cells and regulatory T cells.
These findings demonstrate that resveratrol has some clear biological effects on human circulating immune cells.
Further studies are necessary to interpret the long-term immunological changes associated with resveratrol treatment.
American Psychological Association (APA)
Espinoza, J. Luis& Trung, Ly Quoc& Inaoka, Pleiades T.& Yamada, Kayoko& An, Dao T.& Mizuno, Shohei…[et al.]. 2017. The Repeated Administration of Resveratrol Has Measurable Effects on Circulating T-Cell Subsets in Humans. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1195300
Modern Language Association (MLA)
Espinoza, J. Luis…[et al.]. The Repeated Administration of Resveratrol Has Measurable Effects on Circulating T-Cell Subsets in Humans. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-10.
https://search.emarefa.net/detail/BIM-1195300
American Medical Association (AMA)
Espinoza, J. Luis& Trung, Ly Quoc& Inaoka, Pleiades T.& Yamada, Kayoko& An, Dao T.& Mizuno, Shohei…[et al.]. The Repeated Administration of Resveratrol Has Measurable Effects on Circulating T-Cell Subsets in Humans. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-10.
https://search.emarefa.net/detail/BIM-1195300
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195300