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Pathway-Driven Approaches of Interaction between Oxidative Balance and Genetic Polymorphism on Metabolic Syndrome
Joint Authors
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-16
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Despite evidences of association between basic redox biology and metabolic syndrome (MetS), few studies have evaluated indices that account for multiple oxidative effectors for MetS.
Oxidative balance score (OBS) has indicated the role of oxidative stress in chronic disease pathophysiology.
In this study, we evaluated OBS as an oxidative balance indicator for estimating risk of MetS with 6414 study participants.
OBS is a multiple exogenous factor score for development of disease; therefore, we investigated interplay between oxidative balance and genetic variation for development of MetS focusing on biological pathways by using gene-set-enrichment analysis.
As a result, participants in the highest quartile of OBS were less likely to be at risk for MetS than those in the lowest quartile.
In addition, persons in the highest quartile of OBS had the lowest level of inflammatory markers including C-reactive protein and WBC.
With GWAS-based pathway analysis, we found that VEGF signaling pathway, glutathione metabolism, and Rac-1 pathway were significantly enriched biological pathways involved with OBS on MetS.
These findings suggested that mechanism of angiogenesis, oxidative stress, and inflammation can be involved in interaction between OBS and genetic variation on risk of MetS.
American Psychological Association (APA)
Lee, Ho-Sun& Park, Taesung. 2017. Pathway-Driven Approaches of Interaction between Oxidative Balance and Genetic Polymorphism on Metabolic Syndrome. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1195335
Modern Language Association (MLA)
Lee, Ho-Sun& Park, Taesung. Pathway-Driven Approaches of Interaction between Oxidative Balance and Genetic Polymorphism on Metabolic Syndrome. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-9.
https://search.emarefa.net/detail/BIM-1195335
American Medical Association (AMA)
Lee, Ho-Sun& Park, Taesung. Pathway-Driven Approaches of Interaction between Oxidative Balance and Genetic Polymorphism on Metabolic Syndrome. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-9.
https://search.emarefa.net/detail/BIM-1195335
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195335