Comparison of Glycomacropeptide with Phenylalanine Free-Synthetic Amino Acids in Test Meals to PKU Patients: No Significant Differences in Biomarkers, Including Plasma Phe Levels
Joint Authors
Holst, Jens J.
Pedersen, Michael
Ahring, Kirsten K.
Lund, Allan M.
Jensen, Erik
Jensen, Thomas G.
Brøndum-Nielsen, Karen
Bardow, Allan
Rehfeld, Jens F.
Møller, Lisbeth B.
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-01-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Introduction.
Management of phenylketonuria (PKU) is achieved through low-phenylalanine (Phe) diet, supplemented with low-protein food and mixture of free-synthetic (FS) amino acid (AA).
Casein glycomacropeptide (CGMP) is a natural peptide released in whey during cheese-making and does not contain Phe.
Lacprodan® CGMP-20 used in this study contained a small amount of Phe due to minor presence of other proteins/peptides.
Objective.
The purpose of this study was to compare absorption of CGMP-20 to FSAA with the aim of evaluating short-term effects on plasma AAs as well as biomarkers related to food intake.
Methods.
This study included 8 patients, who had four visits and tested four drink mixtures (DM1–4), consisting of CGMP, FSAA, or a combination.
Plasma blood samples were collected at baseline, 15, 30, 60, 120, and 240 minutes (min) after the meal.
AA profiles and ghrelin were determined 6 times, while surrogate biomarkers were determined at baseline and 240 min.
A visual analogue scale (VAS) was used for evaluation of taste and satiety.
Results.
The surrogate biomarker concentrations and VAS scores for satiety and taste were nonsignificant between the four DMs, and there were only few significant results for AA profiles (not Phe).
Conclusion.
CGMP and FSAA had the overall same nonsignificant short-term effect on biomarkers, including Phe.
This combination of FSAA and CGMP is a suitable supplement for PKU patients.
American Psychological Association (APA)
Ahring, Kirsten K.& Lund, Allan M.& Jensen, Erik& Jensen, Thomas G.& Brøndum-Nielsen, Karen& Pedersen, Michael…[et al.]. 2018. Comparison of Glycomacropeptide with Phenylalanine Free-Synthetic Amino Acids in Test Meals to PKU Patients: No Significant Differences in Biomarkers, Including Plasma Phe Levels. Journal of Nutrition and Metabolism،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1195424
Modern Language Association (MLA)
Ahring, Kirsten K.…[et al.]. Comparison of Glycomacropeptide with Phenylalanine Free-Synthetic Amino Acids in Test Meals to PKU Patients: No Significant Differences in Biomarkers, Including Plasma Phe Levels. Journal of Nutrition and Metabolism No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1195424
American Medical Association (AMA)
Ahring, Kirsten K.& Lund, Allan M.& Jensen, Erik& Jensen, Thomas G.& Brøndum-Nielsen, Karen& Pedersen, Michael…[et al.]. Comparison of Glycomacropeptide with Phenylalanine Free-Synthetic Amino Acids in Test Meals to PKU Patients: No Significant Differences in Biomarkers, Including Plasma Phe Levels. Journal of Nutrition and Metabolism. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1195424
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195424