The Combination of Physical Exercise with Muscle-Directed Antioxidants to Counteract Sarcopenia: A Biomedical Rationale for Pleiotropic Treatment with Creatine and Coenzyme Q10
Joint Authors
Polidori, Emanuela
Fimognari, Carmela
Stocchi, Vilberto
Tiano, Luca
Calcabrini, Cinzia
Genova, Maria Luisa
Silvestri, Sonia
Orlando, Patrik
Sestili, Piero
Guescini, Michele
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-19, 19 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-20
Country of Publication
Egypt
No. of Pages
19
Main Subjects
Abstract EN
Sarcopenia represents an increasing public health risk due to the rapid aging of the world’s population.
It is characterized by both low muscle mass and function and is associated with mobility disorders, increased risk of falls and fractures, loss of independence, disabilities, and increased risk of death.
Despite the urgency of the problem, the development of treatments for sarcopenia has lagged.
Increased reactive oxygen species (ROS) production and decreased antioxidant (AO) defences seem to be important factors contributing to muscle impairment.
Studies have been conducted to verify whether physical exercise and/or AOs could prevent and/or delay sarcopenia through a normalization of the etiologically relevant ROS imbalance.
Despite the strong rationale, the results obtained were contradictory, particularly with regard to the effects of the tested AOs.
A possible explanation might be that not all the agents included in the general heading of “AOs” could fulfill the requisites to counteract the complex series of events causing/accelerating sarcopenia: the combination of the muscle-directed antioxidants creatine and coenzyme Q10 with physical exercise as a biomedical rationale for pleiotropic prevention and/or treatment of sarcopenia is discussed.
American Psychological Association (APA)
Guescini, Michele& Tiano, Luca& Genova, Maria Luisa& Polidori, Emanuela& Silvestri, Sonia& Orlando, Patrik…[et al.]. 2017. The Combination of Physical Exercise with Muscle-Directed Antioxidants to Counteract Sarcopenia: A Biomedical Rationale for Pleiotropic Treatment with Creatine and Coenzyme Q10. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1195434
Modern Language Association (MLA)
Guescini, Michele…[et al.]. The Combination of Physical Exercise with Muscle-Directed Antioxidants to Counteract Sarcopenia: A Biomedical Rationale for Pleiotropic Treatment with Creatine and Coenzyme Q10. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-19.
https://search.emarefa.net/detail/BIM-1195434
American Medical Association (AMA)
Guescini, Michele& Tiano, Luca& Genova, Maria Luisa& Polidori, Emanuela& Silvestri, Sonia& Orlando, Patrik…[et al.]. The Combination of Physical Exercise with Muscle-Directed Antioxidants to Counteract Sarcopenia: A Biomedical Rationale for Pleiotropic Treatment with Creatine and Coenzyme Q10. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-19.
https://search.emarefa.net/detail/BIM-1195434
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195434