Cardiac Development and Transcription Factors: Insulin Signalling, Insulin Resistance, and Intrauterine Nutritional Programming of Cardiovascular Disease
Joint Authors
Govindsamy, Annelene
Naidoo, Strinivasen
Cerf, Marlon E.
Source
Journal of Nutrition and Metabolism
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-02-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Programming with an insult or stimulus during critical developmental life stages shapes metabolic disease through divergent mechanisms.
Cardiovascular disease increasingly contributes to global morbidity and mortality, and the heart as an insulin-sensitive organ may become insulin resistant, which manifests as micro- and/or macrovascular complications due to diabetic complications.
Cardiogenesis is a sequential process during which the heart develops into a mature organ and is regulated by several cardiac-specific transcription factors.
Disrupted cardiac insulin signalling contributes to cardiac insulin resistance.
Intrauterine under- or overnutrition alters offspring cardiac structure and function, notably cardiac hypertrophy, systolic and diastolic dysfunction, and hypertension that precede the onset of cardiovascular disease.
Optimal intrauterine nutrition and oxygen saturation are required for normal cardiac development in offspring and the maintenance of their cardiovascular physiology.
American Psychological Association (APA)
Govindsamy, Annelene& Naidoo, Strinivasen& Cerf, Marlon E.. 2018. Cardiac Development and Transcription Factors: Insulin Signalling, Insulin Resistance, and Intrauterine Nutritional Programming of Cardiovascular Disease. Journal of Nutrition and Metabolism،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1195473
Modern Language Association (MLA)
Govindsamy, Annelene…[et al.]. Cardiac Development and Transcription Factors: Insulin Signalling, Insulin Resistance, and Intrauterine Nutritional Programming of Cardiovascular Disease. Journal of Nutrition and Metabolism No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1195473
American Medical Association (AMA)
Govindsamy, Annelene& Naidoo, Strinivasen& Cerf, Marlon E.. Cardiac Development and Transcription Factors: Insulin Signalling, Insulin Resistance, and Intrauterine Nutritional Programming of Cardiovascular Disease. Journal of Nutrition and Metabolism. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1195473
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195473