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Extracellular Vesicles from Adipose-Derived Mesenchymal Stem Cells Downregulate Senescence Features in Osteoarthritic Osteoblasts
Joint Authors
Tofiño-Vian, Miguel
Pérez del Caz, María Dolores
Castejón, Miguel Angel
Guillén, Maria Isabel
Alcaraz, Maria José
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-05
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Osteoarthritis (OA) affects all articular tissues leading to pain and disability.
The dysregulation of bone metabolism may contribute to the progression of this condition.
Adipose-derived mesenchymal stem cells (ASC) are attractive candidates in the search of novel strategies for OA treatment and exert anti-inflammatory and cytoprotective effects on cartilage.
Chronic inflammation in OA is a relevant factor in the development of cellular senescence and joint degradation.
In this study, we extend our previous observations of ASC paracrine effects to study the influence of conditioned medium and extracellular vesicles from ASC on senescence induced by inflammatory stress in OA osteoblasts.
Our results in cells stimulated with interleukin- (IL-) 1β indicate that conditioned medium, microvesicles, and exosomes from ASC downregulate senescence-associated β-galactosidase activity and the accumulation of γH2AX foci.
In addition, they reduced the production of inflammatory mediators, with the highest effect on IL-6 and prostaglandin E2.
The control of mitochondrial membrane alterations and oxidative stress may provide a mechanism for the protective effects of ASC in OA osteoblasts.
We have also shown that microvesicles and exosomes mediate the paracrine effects of ASC.
Our study suggests that correction of abnormal osteoblast metabolism by ASC products may contribute to their protective effects.
American Psychological Association (APA)
Tofiño-Vian, Miguel& Guillén, Maria Isabel& Pérez del Caz, María Dolores& Castejón, Miguel Angel& Alcaraz, Maria José. 2017. Extracellular Vesicles from Adipose-Derived Mesenchymal Stem Cells Downregulate Senescence Features in Osteoarthritic Osteoblasts. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1195546
Modern Language Association (MLA)
Tofiño-Vian, Miguel…[et al.]. Extracellular Vesicles from Adipose-Derived Mesenchymal Stem Cells Downregulate Senescence Features in Osteoarthritic Osteoblasts. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1195546
American Medical Association (AMA)
Tofiño-Vian, Miguel& Guillén, Maria Isabel& Pérez del Caz, María Dolores& Castejón, Miguel Angel& Alcaraz, Maria José. Extracellular Vesicles from Adipose-Derived Mesenchymal Stem Cells Downregulate Senescence Features in Osteoarthritic Osteoblasts. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1195546
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195546