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Improvement of N-Acetylcysteine Loaded in PLGA Nanoparticles by Nanoprecipitation Method
Joint Authors
Guerrero, Carlos A.
Lancheros, Ruth
Godoy-Silva, Rubén D.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-05
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
N-Acetylcysteine (NAC) is a hydrophilic compound with a low bioavailability.
It has been used as an effective antioxidant agent.
This research seeks to enhance the entrapment of NAC in PLGA nanoparticles for drug delivery systems.
The nanoparticles were made using the nanoprecipitation method and changing the following parameters: the solvent/nonsolvent nature, its viscosity, pH, NAC addition to the nonsolvent, the polymer concentration and molecular weight, and NAC concentration in the solvent.
The results showed that an increase in the nonsolvent viscosity produces NAC concentration in the solvent, and the nonsolvent rises its entrapment in the nanoparticles.
Nanoparticles with 235.5 ± 11.4 nm size with an entrapment efficiency of 0.4 ± 0.04% and a specific load of 3.14 ± 0.33% were obtained.
The results suggest that besides efficiently entrapping hydrophobic compounds, the nanoprecipitation method also has a high potential as an alternative entrapment method for hydrophilic compounds as well.
However, its use in the pharmaceutical industry, as a proper specific load vehicle, still depends on the improvement of the load capacity.
American Psychological Association (APA)
Lancheros, Ruth& Guerrero, Carlos A.& Godoy-Silva, Rubén D.. 2018. Improvement of N-Acetylcysteine Loaded in PLGA Nanoparticles by Nanoprecipitation Method. Journal of Nanotechnology،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1195561
Modern Language Association (MLA)
Lancheros, Ruth…[et al.]. Improvement of N-Acetylcysteine Loaded in PLGA Nanoparticles by Nanoprecipitation Method. Journal of Nanotechnology No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1195561
American Medical Association (AMA)
Lancheros, Ruth& Guerrero, Carlos A.& Godoy-Silva, Rubén D.. Improvement of N-Acetylcysteine Loaded in PLGA Nanoparticles by Nanoprecipitation Method. Journal of Nanotechnology. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1195561
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195561