Antioxidant and Anti-Inflammatory Effects of Shungite against Ultraviolet B Irradiation-Induced Skin Damage in Hairless Mice
Joint Authors
Kim, Cheol-Su
Lee, Kyu-Jae
Sajo, Ma Easter Joy
Shim, Kwang Yong
Kang, Tae-Young
Kim, Soo-Ki
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-13
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
As fullerene-based compound applications have been rapidly increasing in the health industry, the need of biomedical research is urgently in demand.
While shungite is regarded as a natural source of fullerene, it remains poorly documented.
Here, we explored the in vivo effects of shungite against ultraviolet B- (UVB-) induced skin damage by investigating the physiological skin parameters, immune-redox profiling, and oxidative stress molecular signaling.
Toward this, mice were UVB-irradiated with 0.75 mW/cm2 for two consecutive days.
Consecutively, shungite was topically applied on the dorsal side of the mice for 7 days.
First, we found significant improvements in the skin parameters of the shungite-treated groups revealed by the reduction in roughness, pigmentation, and wrinkle measurement.
Second, the immunokine profiling in mouse serum and skin lysates showed a reduction in the proinflammatory response in the shungite-treated groups.
Accordingly, the redox profile of shungite-treated groups showed counterbalance of ROS/RNS and superoxide levels in serum and skin lysates.
Last, we have confirmed the involvement of Nrf2- and MAPK-mediated oxidative stress pathways in the antioxidant mechanism of shungite.
Collectively, the results clearly show that shungite has an antioxidant and anti-inflammatory action against UVB-induced skin damage in hairless mice.
American Psychological Association (APA)
Sajo, Ma Easter Joy& Kim, Cheol-Su& Kim, Soo-Ki& Shim, Kwang Yong& Kang, Tae-Young& Lee, Kyu-Jae. 2017. Antioxidant and Anti-Inflammatory Effects of Shungite against Ultraviolet B Irradiation-Induced Skin Damage in Hairless Mice. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1195596
Modern Language Association (MLA)
Sajo, Ma Easter Joy…[et al.]. Antioxidant and Anti-Inflammatory Effects of Shungite against Ultraviolet B Irradiation-Induced Skin Damage in Hairless Mice. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1195596
American Medical Association (AMA)
Sajo, Ma Easter Joy& Kim, Cheol-Su& Kim, Soo-Ki& Shim, Kwang Yong& Kang, Tae-Young& Lee, Kyu-Jae. Antioxidant and Anti-Inflammatory Effects of Shungite against Ultraviolet B Irradiation-Induced Skin Damage in Hairless Mice. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1195596
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195596