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Uncoupling Protein 2: A Key Player and a Potential Therapeutic Target in Vascular Diseases
Joint Authors
Rubattu, Speranza
Stanzione, Rosita
Forte, Maurizio
Pierelli, Giorgia
Migliarino, Serena
Perelli, Marika
Volpe, Massimo
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-15
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Uncoupling protein 2 (UCP2) is an inner mitochondrial membrane protein that belongs to the uncoupling protein family and plays an important role in lowering mitochondrial membrane potential and dissipating metabolic energy with prevention of oxidative stress accumulation.
In the present article, we will review the evidence that UCP2, as a consequence of its roles within the mitochondria, represents a critical player in the predisposition to vascular disease development in both animal models and in humans, particularly in relation to obesity, diabetes, and hypertension.
The deletion of the UCP2 gene contributes to atherosclerosis lesion development in the knockout mice, also showing significantly shorter lifespan.
The UCP2 gene downregulation is a key determinant of higher predisposition to renal and cerebrovascular damage in an animal model of spontaneous hypertension and stroke.
In contrast, UCP2 overexpression improves both hyperglycemia- and high-salt diet-induced endothelial dysfunction and ameliorates hypertensive target organ damage in SHRSP.
Moreover, drugs (fenofibrate and sitagliptin) and several vegetable compounds (extracts from Brassicaceae, berberine, curcumin, and capsaicin) are able to induce UCP2 expression level and to exert beneficial effects on the occurrence of vascular damage.
As a consequence, UCP2 becomes an interesting therapeutic target for the treatment of common human vascular diseases.
American Psychological Association (APA)
Pierelli, Giorgia& Stanzione, Rosita& Forte, Maurizio& Migliarino, Serena& Perelli, Marika& Volpe, Massimo…[et al.]. 2017. Uncoupling Protein 2: A Key Player and a Potential Therapeutic Target in Vascular Diseases. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1195600
Modern Language Association (MLA)
Pierelli, Giorgia…[et al.]. Uncoupling Protein 2: A Key Player and a Potential Therapeutic Target in Vascular Diseases. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1195600
American Medical Association (AMA)
Pierelli, Giorgia& Stanzione, Rosita& Forte, Maurizio& Migliarino, Serena& Perelli, Marika& Volpe, Massimo…[et al.]. Uncoupling Protein 2: A Key Player and a Potential Therapeutic Target in Vascular Diseases. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1195600
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195600