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Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous System
Joint Authors
Tokay, Tursonjan
Han, Bo
Zhang, Guangming
Sun, Peng
Hou, Shangwei
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-06
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Ether-à-go-go1 (Eag1, Kv10.1, KCNH1) K+ channel is a member of the voltage-gated K+ channel family mainly distributed in the central nervous system and cancer cells.
Like other types of voltage-gated K+ channels, the EAG1 channels are regulated by a variety of endogenous signals including reactive oxygen species, rendering the EAG1 to be in the redox-regulated ion channel family.
The role of EAG1 channels in tumor development and its therapeutic significance have been well established.
Meanwhile, the importance of hEAG1 channels in the nervous system is now increasingly appreciated.
The present review will focus on the recent progress on the channel regulation by endogenous signals and the potential functions of EAG1 channels in normal neuronal signaling as well as neurological diseases.
American Psychological Association (APA)
Han, Bo& Tokay, Tursonjan& Zhang, Guangming& Sun, Peng& Hou, Shangwei. 2017. Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous System. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1195607
Modern Language Association (MLA)
Han, Bo…[et al.]. Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous System. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1195607
American Medical Association (AMA)
Han, Bo& Tokay, Tursonjan& Zhang, Guangming& Sun, Peng& Hou, Shangwei. Eag1 K+ Channel: Endogenous Regulation and Functions in Nervous System. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1195607
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195607