![](/images/graphics-bg.png)
Long-Term Effects of Maternal Deprivation on Redox Regulation in Rat Brain: Involvement of NADPH Oxidase
Joint Authors
Filipović, Branislav
Radonjić, Vidosava
Aleksić, Dubravka
Velimirovic, Milica
Radonjić, Nevena V.
Jevtić, Gordana
Stojković, Tihomir
Poleksić, Joko
Nikolić, Tatjana
Petronijević, Nataša D.
Marković, Branka
Aksić, Milan
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-03-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Maternal deprivation (MD) causes perinatal stress, with subsequent behavioral changes which resemble the symptoms of schizophrenia.
The NADPH oxidase is one of the major generators of reactive oxygen species, known to play a role in stress response in different tissues.
The aim of this study was to elucidate the long-term effects of MD on the expression of NADPH oxidase subunits (gp91phox, p22phox, p67phox, p47phox, and p40phox).
Activities of cytochrome C oxidase and respiratory chain Complex I, as well as the oxidative stress parameters using appropriate spectrophotometric techniques were analyzed.
Nine-day-old Wistar rats were exposed to a 24 h maternal deprivation and sacrificed at young adult age.
The structures affected by perinatal stress, cortex, hippocampus, thalamus, and caudate nuclei were investigated.
The most prominent findings were increased expressions of gp91phox in the cortex and hippocampus, increased expression of p22phox and p40phox, and decreased expression of gp91phox, p22phox, and p47phox in the caudate nuclei.
Complex I activity was increased in all structures except cortex.
Content of reduced glutathione was decreased in all sections while region-specific changes of other oxidative stress parameters were found.
Our results indicate the presence of long-term redox alterations in MD rats.
American Psychological Association (APA)
Marković, Branka& Radonjić, Nevena V.& Jevtić, Gordana& Stojković, Tihomir& Velimirovic, Milica& Aksić, Milan…[et al.]. 2017. Long-Term Effects of Maternal Deprivation on Redox Regulation in Rat Brain: Involvement of NADPH Oxidase. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1195617
Modern Language Association (MLA)
Marković, Branka…[et al.]. Long-Term Effects of Maternal Deprivation on Redox Regulation in Rat Brain: Involvement of NADPH Oxidase. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1195617
American Medical Association (AMA)
Marković, Branka& Radonjić, Nevena V.& Jevtić, Gordana& Stojković, Tihomir& Velimirovic, Milica& Aksić, Milan…[et al.]. Long-Term Effects of Maternal Deprivation on Redox Regulation in Rat Brain: Involvement of NADPH Oxidase. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1195617
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195617