NRF2 Is a Potential Modulator of Hyperresistance to Arsenic Toxicity in Stem-Like Keratinocytes
Joint Authors
Yang, Bei
Fu, Jingqi
Wang, Huihui
Hou, Yongyong
Xu, Yuanyuan
Pi, Jingbo
Wu, Xiafang
Hu, Yuxin
Sun, Ru
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-10
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Arsenic is a well-known human carcinogen.
Stem cells are indicated to be involved in arsenic carcinogenesis and have a survival selection advantage during arsenic exposure with underlying mechanisms undefined.
In the present study, we demonstrated that CD34high-enriched cells derived from HaCaT human keratinocytes showed stem-like phenotypes.
These cells were more resistant to arsenic toxicity and had higher arsenic efflux ability than their mature compartments.
The master transcription factor in antioxidant defense, nuclear factor erythroid 2-related factor 2 (NRF2) with its downstream genes, was highly expressed in CD34high-enriched cells.
Stable knockdown of NRF2 abolished the hyperresistance to arsenic toxicity and holoclone-forming ability of CD34high-enriched cells.
Our results suggest that skin epithelial stem/progenitor cells are more resistant to arsenic toxicity than mature cells, which is associated with the high innate expression of NRF2 in skin epithelial stem/progenitor cells.
American Psychological Association (APA)
Wu, Xiafang& Yang, Bei& Hu, Yuxin& Sun, Ru& Wang, Huihui& Fu, Jingqi…[et al.]. 2017. NRF2 Is a Potential Modulator of Hyperresistance to Arsenic Toxicity in Stem-Like Keratinocytes. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1195635
Modern Language Association (MLA)
Wu, Xiafang…[et al.]. NRF2 Is a Potential Modulator of Hyperresistance to Arsenic Toxicity in Stem-Like Keratinocytes. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1195635
American Medical Association (AMA)
Wu, Xiafang& Yang, Bei& Hu, Yuxin& Sun, Ru& Wang, Huihui& Fu, Jingqi…[et al.]. NRF2 Is a Potential Modulator of Hyperresistance to Arsenic Toxicity in Stem-Like Keratinocytes. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1195635
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195635