Effect of Neonatal Exposure to Poly(Ethylene Glycol)-block-Poly(Lactic Acid) Nanoparticles on Oxidative State in Infantile and Adult Female Rats
Joint Authors
Laubertova, Lucia
Žitňanová, Ingrid
Dvořáková, Monika
Rollerová, Eva
Scsuková, Soňa
Bujňáková Mlynarčíková, Alžbeta
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-10
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Our goal was to evaluate the potential health risk of the polymeric NP, poly(ethylene glycol)-block-poly(lactic acid) (PEG-b-PLA), from the view of redox imbalance of the organism in two different life stages.
Female Wistar rats were neonatally administered intraperitoneally with PEG-b-PLA NPs [20 mg/kg of b.w.
(PEG20) or 40 (PEG40) mg/kg of b.w.] from postnatal day 4 (PND4) to PND7.
We measured antioxidant capacity (TEAC), level of protein carbonyls and lipoperoxides in plasma, activities of catalase, glutathione peroxidase (GPx), and superoxide dismutase (SOD) in hemolysates of infantile (sacrificed on PND17) and adult (sacrificed after PND176) rats.
Compared to controls, neonatal PEG40 exposure induced a significant TEAC reduction in the infantile rats.
Protein carbonyls and lipoperoxide levels were not affected after any dose of PEG-b-PLA NP administration.
In adult rats, PEG20 administration caused a significant decrease of protein carbonyl levels compared to controls.
In infantile rats, both doses of PEG-b-PLA NP administration increased catalase, Gpx, and SOD activities compared to controls.
Surprisingly, in adult rats, the activities of Gpx and SOD decreased significantly after administration of both doses of PEG-b-PLA NPs.
Obtained data indicate a possible age-related association between the oxidative status and neonatal PEG-b-PLA NP administration in female rats.
American Psychological Association (APA)
Dvořáková, Monika& Rollerová, Eva& Scsuková, Soňa& Bujňáková Mlynarčíková, Alžbeta& Laubertova, Lucia& Žitňanová, Ingrid. 2017. Effect of Neonatal Exposure to Poly(Ethylene Glycol)-block-Poly(Lactic Acid) Nanoparticles on Oxidative State in Infantile and Adult Female Rats. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1195659
Modern Language Association (MLA)
Dvořáková, Monika…[et al.]. Effect of Neonatal Exposure to Poly(Ethylene Glycol)-block-Poly(Lactic Acid) Nanoparticles on Oxidative State in Infantile and Adult Female Rats. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1195659
American Medical Association (AMA)
Dvořáková, Monika& Rollerová, Eva& Scsuková, Soňa& Bujňáková Mlynarčíková, Alžbeta& Laubertova, Lucia& Žitňanová, Ingrid. Effect of Neonatal Exposure to Poly(Ethylene Glycol)-block-Poly(Lactic Acid) Nanoparticles on Oxidative State in Infantile and Adult Female Rats. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1195659
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195659