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Sirt1 Inhibits Oxidative Stress in Vascular Endothelial Cells
Joint Authors
Zeng, Zhenhua
Chen, Zhongqing
Zhang, Weijin
Zhang, Yaoyuan
Wu, Jie
Huang, Qiaobing
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-05-04
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The vascular endothelium is a layer of cells lining the inner surface of vessels, serving as a barrier that mediates microenvironment homeostasis.
Deterioration of either the structure or function of endothelial cells (ECs) results in a variety of cardiovascular diseases.
Previous studies have shown that reactive oxygen species (ROS) is a key factor that contributes to the impairment of ECs and the subsequent endothelial dysfunction.
The longevity regulator Sirt1 is a NAD+-dependent deacetylase that has a potential antioxidative stress activity in vascular ECs.
The mechanisms underlying the protective effects involve Sirt1/FOXOs, Sirt1/NF-κB, Sirt1/NOX, Sirt1/SOD, and Sirt1/eNOs pathways.
In this review, we summarize the most recent reports in this field to recapitulate the potent mechanisms involving the protective role of Sirt1 in oxidative stress and to highlight the beneficial effects of Sirt1 on cardiovascular functions.
American Psychological Association (APA)
Zhang, Weijin& Huang, Qiaobing& Zeng, Zhenhua& Wu, Jie& Zhang, Yaoyuan& Chen, Zhongqing. 2017. Sirt1 Inhibits Oxidative Stress in Vascular Endothelial Cells. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1195696
Modern Language Association (MLA)
Zhang, Weijin…[et al.]. Sirt1 Inhibits Oxidative Stress in Vascular Endothelial Cells. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1195696
American Medical Association (AMA)
Zhang, Weijin& Huang, Qiaobing& Zeng, Zhenhua& Wu, Jie& Zhang, Yaoyuan& Chen, Zhongqing. Sirt1 Inhibits Oxidative Stress in Vascular Endothelial Cells. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1195696
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195696