Biological Effect of Organically Coated Grias neuberthii and Persea americana Silver Nanoparticles on HeLa and MCF-7 Cancer Cell Lines
Joint Authors
Grijalva, Marcelo
Vallejo, María José
Salazar, Lizeth
Castillo, Luis
Maldonado, Alexander
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The aim of this study was to assess the biological effect of organically coated Grias neuberthii (piton) fruit and Persea americana (avocado) leaves nanoparticles (NPs) on cervical cancer (HeLa) and breast adenocarcinoma (MCF-7) cells with an emphasis on gene expression (p53 transcription factor and glutathione-S-transferase GST) and cell viability.
UV-Vis spectroscopy analysis showed that synthesized AgNPs remained partially stable under cell culture conditions.
HeLa cells remained viable when exposed to piton and avocado AgNPs.
A statistically significant, dose-dependent cytotoxic response to both AgNPs was found on the breast cancer (MCF-7) cell line at concentrations above 50 µM.
While expression levels of transcription factor p53 showed downregulation in treated MCF-7 and HeLa cells, GST expression was not affected in both cell lines treated.
Cell viability assays along with gene expression levels in treated MCF-7 cells support a cancer cell population undergoing cell cycle arrest.
The selective toxicity of biosynthesized piton/avocado AgNPs on MCF-7 cells might be of value for novel therapeutics.
American Psychological Association (APA)
Salazar, Lizeth& Vallejo, María José& Grijalva, Marcelo& Castillo, Luis& Maldonado, Alexander. 2018. Biological Effect of Organically Coated Grias neuberthii and Persea americana Silver Nanoparticles on HeLa and MCF-7 Cancer Cell Lines. Journal of Nanotechnology،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1195713
Modern Language Association (MLA)
Salazar, Lizeth…[et al.]. Biological Effect of Organically Coated Grias neuberthii and Persea americana Silver Nanoparticles on HeLa and MCF-7 Cancer Cell Lines. Journal of Nanotechnology No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1195713
American Medical Association (AMA)
Salazar, Lizeth& Vallejo, María José& Grijalva, Marcelo& Castillo, Luis& Maldonado, Alexander. Biological Effect of Organically Coated Grias neuberthii and Persea americana Silver Nanoparticles on HeLa and MCF-7 Cancer Cell Lines. Journal of Nanotechnology. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1195713
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195713