The Role of the Vagus Nerve in Cancer Prognosis: A Systematic and a Comprehensive Review
Joint Authors
De Couck, Marijke
Caers, Ralf
Spiegel, David
Gidron, Yori
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-07-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
This article reviews the role of the vagus nerve in tumor modulation and cancer prognosis.
We present a systematic review of 12 epidemiological studies examining the relationship between heart rate variability, the main vagus nerve index, and prognosis in cancer patients (survival and tumor markers).
These studies show that initially high vagal nerve activity predicts better cancer prognosis, and, in some studies, independent of confounders such as cancer stage and treatments.
Since the design of the epidemiological studies is correlational, any causal relationship between heart rate variability and cancer prognosis cannot be inferred.
However, various semi-experimental cohort studies in humans and experimental studies in animals have examined this causal relationship.
The second part of this paper presents a comprehensive review including human and animal cohort and experimental studies showing that vagotomy accelerates tumor growth, while vagal nerve activation improves cancer prognosis.
Based on all reviewed studies, it is concluded that the evidence supports a protective role of the vagus nerve in cancer and specifically in the metastatic stage.
American Psychological Association (APA)
De Couck, Marijke& Caers, Ralf& Spiegel, David& Gidron, Yori. 2018. The Role of the Vagus Nerve in Cancer Prognosis: A Systematic and a Comprehensive Review. Journal of Oncology،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1195731
Modern Language Association (MLA)
De Couck, Marijke…[et al.]. The Role of the Vagus Nerve in Cancer Prognosis: A Systematic and a Comprehensive Review. Journal of Oncology No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1195731
American Medical Association (AMA)
De Couck, Marijke& Caers, Ralf& Spiegel, David& Gidron, Yori. The Role of the Vagus Nerve in Cancer Prognosis: A Systematic and a Comprehensive Review. Journal of Oncology. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1195731
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195731