Complex Karyotype in Hematological Diseases: A 6-Year Single Centre Study from Pakistan
Joint Authors
Maqsood, S.
Shamsi, Tahir
Waheed, Samra
Hassan, Jawad
Naz, Maliha
Abid, Madiha
Shan, Saira
Nadeem, Muhammad
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-06-03
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Background.
Most of the hematological disorders are heterogenous with regard to morphology, immunophenotype, and genetic rearrangements.
Multiple recurrent chromosomal aberrations have been identified by conventional cytogenetic analysis, which is now widely recognized as one of the most important diagnostic and prognostic determinants in these patients.
Though rarer, complex karyotype has been associated with worst prognosis.
Materials and Methods.
A total of 1185 bone marrow or peripheral blood cytogenetics samples were taken with different hematological diseases.
They included both benign and malignant disease entities.
In each case, cells were cultured and conventional cytogenetic analysis was performed.
Results.
Among 1185 subjects, 41 (3.4%) patients possessed complex cytogenetic abnormalities.
Out of these 41, 33 (80%) were males.
The mean age was 37 years (median age 39 years).
Myelodysplastic syndromes had the most numbers of complex karyotypes (8%), followed by acute myeloid leukemia (7%) and acute lymphoblastic leukemia (4%).
Also we found few patients with acute promyelocytic leukemia, aplastic anemia , chronic myeloid leukemia, and diffuse large B cell Lymphoma possessing complex karyotype.
Frequencies of different cytogenetic abnormalities were assessed with respect to disease as well as independently.
Trisomy 21 was the most common chromosomal abnormality found in 28% of patients.
Conclusion.
Complex karyotype was most frequently associated with myelodysplastic syndromes and acute myeloid leukemia.
Trisomy 21 and deletion 5q were the commonest cytogenetic abnormalities found.
We also assessed complex karyotype in benign diseases and detected one patient of aplastic anemia with complex karyotype.
This is the first study highlighting the presence of complex karyotypes in hematological disorders in our region.
American Psychological Association (APA)
Waheed, Samra& Hassan, Jawad& Naz, Maliha& Maqsood, S.& Abid, Madiha& Shan, Saira…[et al.]. 2018. Complex Karyotype in Hematological Diseases: A 6-Year Single Centre Study from Pakistan. Journal of Oncology،Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1195754
Modern Language Association (MLA)
Waheed, Samra…[et al.]. Complex Karyotype in Hematological Diseases: A 6-Year Single Centre Study from Pakistan. Journal of Oncology No. 2018 (2018), pp.1-5.
https://search.emarefa.net/detail/BIM-1195754
American Medical Association (AMA)
Waheed, Samra& Hassan, Jawad& Naz, Maliha& Maqsood, S.& Abid, Madiha& Shan, Saira…[et al.]. Complex Karyotype in Hematological Diseases: A 6-Year Single Centre Study from Pakistan. Journal of Oncology. 2018. Vol. 2018, no. 2018, pp.1-5.
https://search.emarefa.net/detail/BIM-1195754
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195754