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Homocysteine and Digestive Tract Cancer Risk: A Dose-Response Meta-Analysis
Joint Authors
Zhao, Xin
Xu, Jun
Li, Chujun
Wang, Wei
Zhu, Lingjun
Sun, Shanwen
Ni, Peng
Ren, Anjing
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-18
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Background.
Homocysteine, a key component in one-carbon metabolism, is of great importance in remethylation.
Many epidemiologic studies have assessed the association between homocysteine and risk of digestive tract cancer, but the results are inconsistent.
Objective.
The objective of our meta-analysis is to assess the association between homocysteine and digestive tract cancer risk.
Methods.
Comprehensive searches were performed on the PubMed, Embase, Cochrane, and Web of Science databases up to September 25, 2018, to identify relevant studies.
Thirteen studies were included in the meta-analysis.
Odds ratios (ORs) and their corresponding 95% confidence intervals (95% CIs) were used to estimate the strength of the relationship between homocysteine and the risk of digestive tract cancer.
Results.
The pooled OR of digestive tract cancer risk for patients with the highest categories of blood homocysteine levels versus the lowest categories was 1.27 (95% CI, 1.15, 1.39) with no significant heterogeneity observed (P = 0.798, I2 = 0.0%).
Moreover, the dose-response analysis revealed that each 5μmol/L increase in homocysteine increased the incidence of digestive tract cancer by 7%.
Conclusion.
Generally, our results indicated that elevated homocysteine was associated with higher risk of digestive tract cancer.
That is, homocysteine concentration may be a potential biomarker for occurrence of digestive tract cancer.
American Psychological Association (APA)
Xu, Jun& Zhao, Xin& Sun, Shanwen& Ni, Peng& Li, Chujun& Ren, Anjing…[et al.]. 2018. Homocysteine and Digestive Tract Cancer Risk: A Dose-Response Meta-Analysis. Journal of Oncology،Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1195778
Modern Language Association (MLA)
Xu, Jun…[et al.]. Homocysteine and Digestive Tract Cancer Risk: A Dose-Response Meta-Analysis. Journal of Oncology No. 2018 (2018), pp.1-12.
https://search.emarefa.net/detail/BIM-1195778
American Medical Association (AMA)
Xu, Jun& Zhao, Xin& Sun, Shanwen& Ni, Peng& Li, Chujun& Ren, Anjing…[et al.]. Homocysteine and Digestive Tract Cancer Risk: A Dose-Response Meta-Analysis. Journal of Oncology. 2018. Vol. 2018, no. 2018, pp.1-12.
https://search.emarefa.net/detail/BIM-1195778
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195778