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Multiple Myeloma of the Central Nervous System: 13 Cases and Review of the Literature
Joint Authors
Varga, Gergely
Mikala, Gábor
Gopcsa, László
Csukly, Zoltán
Kollai, Sarolta
Balázs, György
Botond, Tímár
Wohner, Nikolett
Horváth, Laura
Szombath, Gergely
Farkas, Péter
Masszi, Tamás
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-04-23
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Central nervous system involvement is a rare complication of multiple myeloma with extremely poor prognosis as it usually fails to respond to therapy.
We present 13 cases diagnosed at two centers in Budapest and review the current literature.
The majority of our cases presented with high-risk features initially; two had plasma cell leukemia.
Repeated genetic tests showed clonal evolution in 3 cases.
Treatments varied according to the era, and efficacy was poor as generally reported in the literature.
Only one patient is currently alive, with 3-month follow-up, and the patient responded to daratumumab-based treatment.
Recent case reports show promising effectivity of pomalidomide and marizomib.
American Psychological Association (APA)
Varga, Gergely& Mikala, Gábor& Gopcsa, László& Csukly, Zoltán& Kollai, Sarolta& Balázs, György…[et al.]. 2018. Multiple Myeloma of the Central Nervous System: 13 Cases and Review of the Literature. Journal of Oncology،Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1195786
Modern Language Association (MLA)
Varga, Gergely…[et al.]. Multiple Myeloma of the Central Nervous System: 13 Cases and Review of the Literature. Journal of Oncology No. 2018 (2018), pp.1-7.
https://search.emarefa.net/detail/BIM-1195786
American Medical Association (AMA)
Varga, Gergely& Mikala, Gábor& Gopcsa, László& Csukly, Zoltán& Kollai, Sarolta& Balázs, György…[et al.]. Multiple Myeloma of the Central Nervous System: 13 Cases and Review of the Literature. Journal of Oncology. 2018. Vol. 2018, no. 2018, pp.1-7.
https://search.emarefa.net/detail/BIM-1195786
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195786