Effects of Chimonanthus nitens Oliv. Leaf Extract on Glycolipid Metabolism and Antioxidant Capacity in Diabetic Model Mice
Joint Authors
Chen, Hui
Jiang, Yan
Yang, Zhanwei
Hu, Wenbing
Xiong, Lei
Wang, Ning
Liu, Xin
Zheng, Guodong
Ouyang, Kehui
Wang, Wenjun
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-09-19
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The paper investigated the antihyperglycemic and antihyperlipidemic efficacy and antioxidant capacity of Chimonanthus nitens Oliv.
leaf extract (COE) in combination of high-glucose-fat diet-fed and streptozotocin-induced diabetic model mice.
Various physiological indexes in diabetic model mice were well improved especially by oral administration of high dose of COE; the results were listed as follows.
Fast blood glucose (FBG) level and serum triglyceride (TC), total cholesterol (TG), low-density lipoprotein cholesterol (LDLC), and malondialdehyde (MDA) as well as MDA in liver were significantly reduced; fasting serum insulin (FINS) and insulin sensitivity index (ISI) were both increased; high-density lipoprotein cholesterol (HDLC) in serum was significantly increased; total antioxidant capacity (T-AOC), activities of superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) in serum and liver were apparently enhanced; liver coefficient (LC), liver transaminase, and alkaline phosphatase (ALP) were decreased.
Furthermore, pancreas islets and liver in diabetic model mice showed some extend of improvement in morphology and function after 4 weeks of COE treatment.
In consequence, COE was advantageous to regulate glycolipid metabolism and elevate antioxidant capacity in diabetic model mice.
Thus, the present study will provide a scientific evidence for the use of COE in the management of diabetes and its related complications.
American Psychological Association (APA)
Chen, Hui& Jiang, Yan& Yang, Zhanwei& Hu, Wenbing& Xiong, Lei& Wang, Ning…[et al.]. 2017. Effects of Chimonanthus nitens Oliv. Leaf Extract on Glycolipid Metabolism and Antioxidant Capacity in Diabetic Model Mice. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1195793
Modern Language Association (MLA)
Chen, Hui…[et al.]. Effects of Chimonanthus nitens Oliv. Leaf Extract on Glycolipid Metabolism and Antioxidant Capacity in Diabetic Model Mice. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-11.
https://search.emarefa.net/detail/BIM-1195793
American Medical Association (AMA)
Chen, Hui& Jiang, Yan& Yang, Zhanwei& Hu, Wenbing& Xiong, Lei& Wang, Ning…[et al.]. Effects of Chimonanthus nitens Oliv. Leaf Extract on Glycolipid Metabolism and Antioxidant Capacity in Diabetic Model Mice. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-11.
https://search.emarefa.net/detail/BIM-1195793
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195793