Proinflammatory Cytokines Are Soluble Mediators Linked with Ventricular Arrhythmias and Contractile Dysfunction in a Rat Model of Metabolic Syndrome
Joint Authors
Castillo, E. C.
Carvajal, Karla
Elizondo-Montemayor, Leticia
Silva-Platas, Christian
Torres-Quintanilla, Alejandro
Garcia-Rivas, Gerardo
Treviño-Saldaña, Niria
Oropeza-Almazán, Yuriana
Fernández-Sada, Evaristo
García, Noemí
Willis, B. Cicero
Rodríguez-Rodríguez, César
De la Peña, Erasmo
Bernal-Ramírez, Judith
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-19
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Metabolic syndrome (MS) increases cardiovascular risk and is associated with cardiac dysfunction and arrhythmias, although the precise mechanisms are still under study.
Chronic inflammation in MS has emerged as a possible cause of adverse cardiac events.
Male Wistar rats fed with 30% sucrose in drinking water and standard chow for 25–27 weeks were compared to a control group.
The MS group showed increased weight, visceral fat, blood pressure, and serum triglycerides.
The most important increases in serum cytokines included IL-1β (7-fold), TNF-α (84%), IL-6 (41%), and leptin (2-fold), the latter also showing increased gene expression in heart tissue (35-fold).
Heart function ex vivo in MS group showed a decreased mechanical performance response to isoproterenol challenge (ISO).
Importantly, MS hearts under ISO showed nearly twofold the incidence of ventricular fibrillation.
Healthy rat cardiomyocytes exposed to MS group serum displayed impaired contractile function and Ca2+ handling during ISO treatment, showing slightly decreased cell shortening and Ca2+ transient amplitude (23%), slower cytosolic calcium removal (17%), and more frequent spontaneous Ca2+ release events (7.5-fold).
As spontaneous Ca2+ releases provide a substrate for ventricular arrhythmias, our study highlights the possible role of serum proinflammatory mediators in the development of arrhythmic events during MS.
American Psychological Association (APA)
Fernández-Sada, Evaristo& Torres-Quintanilla, Alejandro& Silva-Platas, Christian& García, Noemí& Willis, B. Cicero& Rodríguez-Rodríguez, César…[et al.]. 2017. Proinflammatory Cytokines Are Soluble Mediators Linked with Ventricular Arrhythmias and Contractile Dysfunction in a Rat Model of Metabolic Syndrome. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1195801
Modern Language Association (MLA)
Fernández-Sada, Evaristo…[et al.]. Proinflammatory Cytokines Are Soluble Mediators Linked with Ventricular Arrhythmias and Contractile Dysfunction in a Rat Model of Metabolic Syndrome. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1195801
American Medical Association (AMA)
Fernández-Sada, Evaristo& Torres-Quintanilla, Alejandro& Silva-Platas, Christian& García, Noemí& Willis, B. Cicero& Rodríguez-Rodríguez, César…[et al.]. Proinflammatory Cytokines Are Soluble Mediators Linked with Ventricular Arrhythmias and Contractile Dysfunction in a Rat Model of Metabolic Syndrome. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1195801
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195801