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MiR-30a: A Novel Biomarker and Potential Therapeutic Target for Cancer
Joint Authors
Tang, Jin-Hai
Jiang, Lin-hong
Zhang, He-da
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-08-06
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
MicroRNAs (miRNAs) are small, highly conserved noncoding RNAs molecules, consisting of 18–25 nucleotides that regulate gene expression by binding to complementary binding sites within the 3′untranslated region (3′UTR) of target mRNAs.
MiRNAs have been involved in regulating gene expression and diverse physiological and pathological processes.
Several studies have reported that miR-30a, situated on chromosome 6q.13, is produced by an intronic transcriptional unit.
Moreover, miR-30a has demonstrated its role in biological processes, including inhibiting proliferation and metastasis in many tumors, autophagy in chronic myelogenous leukemia, and regulating TGF-b1-induced epithelial-mesenchymal transition.
However, based on the pathogenetic relationship between miR-30a and cancer in tumorigenesis, we believe that miR-30a may serve as tumor promising biomarker.
Moreover, it would offer a therapeutic target for the treatment of cancer.
American Psychological Association (APA)
Jiang, Lin-hong& Zhang, He-da& Tang, Jin-Hai. 2018. MiR-30a: A Novel Biomarker and Potential Therapeutic Target for Cancer. Journal of Oncology،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1195806
Modern Language Association (MLA)
Jiang, Lin-hong…[et al.]. MiR-30a: A Novel Biomarker and Potential Therapeutic Target for Cancer. Journal of Oncology No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1195806
American Medical Association (AMA)
Jiang, Lin-hong& Zhang, He-da& Tang, Jin-Hai. MiR-30a: A Novel Biomarker and Potential Therapeutic Target for Cancer. Journal of Oncology. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1195806
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195806