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Pitaya Extracts Induce Growth Inhibition and Proapoptotic Effects on Human Cell Lines of Breast Cancer via Downregulation of Estrogen Receptor Gene Expression
Joint Authors
Bauer, Deborah
Teodoro, Anderson Junger
de Oliveira, Felipe Leite
De Castro, Danielle dos Santos Bonfim
Nogueira, Eduardo Matos
Silva, Marco Antônio Mota da
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-07-06
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Breast cancer is one of the most prevalent cancers in the world and is also the leading cause of cancer death in women.
The use of bioactive compounds of functional foods contributes to reduce the risk of chronic diseases, such as cancer and vascular disorders.
In this study, we evaluated the antioxidant potential and the influence of pitaya extract (PE) on cell viability, colony formation, cell cycle, apoptosis, and expression of BRCA1, BRCA2, PRAB, and Erα in breast cancer cell lines (MCF-7 and MDA-MB-435).
PE showed high antioxidant activity and high values of anthocyanins (74.65 ± 2.18).
We observed a selective decrease in cell proliferation caused by PE in MCF-7 (ER+) cell line.
Cell cycle analysis revealed that PE induced an increase in G0/G1 phase followed by a decrease in G2/M phase.
Also, PE induced apoptosis in MCF-7 (ER+) cell line and suppressed BRCA1, BRCA2, PRAB, and Erα gene expression.
Finally, we also demonstrate that no effect was observed with MDA-MB-435 cells (ER−) after PE treatment.
Taken together, the present study suggests that pitaya may have a protective effect against breast cancer.
American Psychological Association (APA)
Bauer, Deborah& De Castro, Danielle dos Santos Bonfim& de Oliveira, Felipe Leite& Nogueira, Eduardo Matos& Silva, Marco Antônio Mota da& Teodoro, Anderson Junger. 2017. Pitaya Extracts Induce Growth Inhibition and Proapoptotic Effects on Human Cell Lines of Breast Cancer via Downregulation of Estrogen Receptor Gene Expression. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1195816
Modern Language Association (MLA)
Bauer, Deborah…[et al.]. Pitaya Extracts Induce Growth Inhibition and Proapoptotic Effects on Human Cell Lines of Breast Cancer via Downregulation of Estrogen Receptor Gene Expression. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1195816
American Medical Association (AMA)
Bauer, Deborah& De Castro, Danielle dos Santos Bonfim& de Oliveira, Felipe Leite& Nogueira, Eduardo Matos& Silva, Marco Antônio Mota da& Teodoro, Anderson Junger. Pitaya Extracts Induce Growth Inhibition and Proapoptotic Effects on Human Cell Lines of Breast Cancer via Downregulation of Estrogen Receptor Gene Expression. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1195816
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195816