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Oxidative Modification of Blood Serum Proteins in Multiple Sclerosis after Interferon Beta and Melatonin Treatment
Joint Authors
Bartosz, G.
Galiniak, Sabina
Adamczyk-Sowa, Monika
Sowa, Paweł
Żyracka, Ewa
Grzesik, Michalina
Naparło, Katarzyna
Sadowska-Bartosz, Izabela
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-18
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Multiple sclerosis (MS) is a disease involving oxidative stress (OS).
This study was aimed at examination of the effect of melatonin supplementation on OS parameters, especially oxidative protein modifications of blood serum proteins, in MS patients.
The study included 11 control subjects, 14 de novo diagnosed MS patients with the relapsing-remitting form of MS (RRMS), 36 patients with RRMS receiving interferon beta-1b (250 μg every other day), and 25 RRMS patients receiving interferon beta-1b plus melatonin (5 mg daily).
The levels of N′-formylkynurenine, kynurenine, dityrosine, carbonyl groups, advanced glycation products (AGEs), advanced oxidation protein products (AOPP), and malondialdehyde were elevated in nontreated RRSM patients.
N′-Formylkynurenine, kynurenine, AGEs, and carbonyl contents were decreased only in the group treated with interferon beta plus melatonin, while dityrosine and AOPP contents were decreased both in the group of patients treated with interferon beta and in the group treated with interferon beta-1b plus melatonin.
These results demonstrate that melatonin ameliorates OS in MS patients supporting the view that combined administration of interferon beta-1b and melatonin can be more effective in reducing OS in MS patients than interferon beta-1b alone.
American Psychological Association (APA)
Adamczyk-Sowa, Monika& Galiniak, Sabina& Żyracka, Ewa& Grzesik, Michalina& Naparło, Katarzyna& Sowa, Paweł…[et al.]. 2017. Oxidative Modification of Blood Serum Proteins in Multiple Sclerosis after Interferon Beta and Melatonin Treatment. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1195820
Modern Language Association (MLA)
Adamczyk-Sowa, Monika…[et al.]. Oxidative Modification of Blood Serum Proteins in Multiple Sclerosis after Interferon Beta and Melatonin Treatment. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1195820
American Medical Association (AMA)
Adamczyk-Sowa, Monika& Galiniak, Sabina& Żyracka, Ewa& Grzesik, Michalina& Naparło, Katarzyna& Sowa, Paweł…[et al.]. Oxidative Modification of Blood Serum Proteins in Multiple Sclerosis after Interferon Beta and Melatonin Treatment. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1195820
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195820