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P-glycoprotein (ABCB1) and Oxidative Stress: Focus on Alzheimer’s Disease
Joint Authors
Sita, Giulia
Hrelia, Patrizia
Morroni, Fabiana
Tarozzi, Andrea
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-11-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
ATP-binding cassette (ABC) transporters, in particular P-glycoprotein (encoded by ABCB1), are important and selective elements of the blood-brain barrier (BBB), and they actively contribute to brain homeostasis.
Changes in ABCB1 expression and/or function at the BBB may not only alter the expression and function of other molecules at the BBB but also affect brain environment.
Over the last decade, a number of reports have shown that ABCB1 actively mediates the transport of beta amyloid (Aβ) peptide.
This finding has opened up an entirely new line of research in the field of Alzheimer’s disease (AD).
Indeed, despite intense research efforts, AD remains an unsolved pathology and effective therapies are still unavailable.
Here, we review the crucial role of ABCB1 in the Aβ transport and how oxidative stress may interfere with this process.
A detailed understanding of ABCB1 regulation can provide the basis for improved neuroprotection in AD and also enhanced therapeutic drug delivery to the brain.
American Psychological Association (APA)
Sita, Giulia& Hrelia, Patrizia& Tarozzi, Andrea& Morroni, Fabiana. 2017. P-glycoprotein (ABCB1) and Oxidative Stress: Focus on Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1195824
Modern Language Association (MLA)
Sita, Giulia…[et al.]. P-glycoprotein (ABCB1) and Oxidative Stress: Focus on Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1195824
American Medical Association (AMA)
Sita, Giulia& Hrelia, Patrizia& Tarozzi, Andrea& Morroni, Fabiana. P-glycoprotein (ABCB1) and Oxidative Stress: Focus on Alzheimer’s Disease. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1195824
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195824