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The Short Isoform of DNAJB6 Protects against 1-Methyl-4-phenylpridinium Ion-Induced Apoptosis in LN18 Cells via Inhibiting Both ROS Formation and Mitochondrial Membrane Potential Loss
Joint Authors
Yeo, Sujung
Lee, Sook-Hyun
Lee, Seo-Yeon
Hong, Yeon-Mi
Hong, Yohan
Choi, Yeong-Gon
Jin, Soo Hee
Sung, Backil
Jung, Hyejin
Lim, Sabina
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
In a previous study, we found that the short isoform of DNAJB6 (DNAJB6(S)) had been decreased in the striatum of a mouse model of Parkinson’s disease (PD) induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).
DNAJB6, one of the heat shock proteins, has been implicated in the pathogenesis of PD.
In this study, we explored the cytoprotective effect of DNAJB6(S) against 1-methyl-4-phenylpyridinium ion- (MPP+-) induced apoptosis and the underlying molecular mechanisms in cultured LN18 cells from astrocytic tumors.
We observed that MPP+ significantly reduced the cell viability and induced apoptosis in LN18 glioblastoma cells.
DNAJB6(S) protected LN18 cells against MPP+-induced apoptosis not only by suppressing Bax cleavage but also by inhibiting a series of apoptotic events including loss of mitochondrial membrane potential, increase in intracellular reactive oxygen species, and activation of caspase-9.
These observations suggest that the cytoprotective effects of DNAJB6(S) may be mediated, at least in part, by the mitochondrial pathway of apoptosis.
American Psychological Association (APA)
Hong, Yeon-Mi& Hong, Yohan& Choi, Yeong-Gon& Yeo, Sujung& Jin, Soo Hee& Lee, Seo-Yeon…[et al.]. 2017. The Short Isoform of DNAJB6 Protects against 1-Methyl-4-phenylpridinium Ion-Induced Apoptosis in LN18 Cells via Inhibiting Both ROS Formation and Mitochondrial Membrane Potential Loss. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1195851
Modern Language Association (MLA)
Hong, Yeon-Mi…[et al.]. The Short Isoform of DNAJB6 Protects against 1-Methyl-4-phenylpridinium Ion-Induced Apoptosis in LN18 Cells via Inhibiting Both ROS Formation and Mitochondrial Membrane Potential Loss. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-12.
https://search.emarefa.net/detail/BIM-1195851
American Medical Association (AMA)
Hong, Yeon-Mi& Hong, Yohan& Choi, Yeong-Gon& Yeo, Sujung& Jin, Soo Hee& Lee, Seo-Yeon…[et al.]. The Short Isoform of DNAJB6 Protects against 1-Methyl-4-phenylpridinium Ion-Induced Apoptosis in LN18 Cells via Inhibiting Both ROS Formation and Mitochondrial Membrane Potential Loss. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-12.
https://search.emarefa.net/detail/BIM-1195851
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195851