The Plasticity of CD4+CD25+FOXP3+CD127low T Cells in Patients with Metastatic Renal Cell Carcinoma in the Course of Interferon-Alpha Immunotherapy
Joint Authors
Sayapina, M. S.
Bykovskaia, Svetlana N.
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-05-02
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Aims.
To examine changes in subpopulation of CD4+CD25+Foxp3+CD127low T lymphocytes (Treg) and their association with the efficiency of the IFN-α therapy.
Materials and Methods.
Pts with mRCC who had undergone nephrectomy were treated with IFN-α at a dose of 6 × 10 6 U/day three times a week (n = 18).
An immunophenotypic analysis of lymphocytes in peripheral blood expressing CD4, CD25, CD127, and Foxp3 antigens could be performed in 18 pts before, 2 weeks, and 2 mo after IFN-α therapy and 22 normal volunteers.
Blood samples were collected at baseline and 2 mo after treatment start.
Serum levels of TGF-β1, IL-17A, and Epo were measured by ELISA.
Results.
PR was achieved in 3 (16.6%) pts who received first-line therapy.
Long-lasting SD (≥6 months) was noted in 6 (33.3%) pts.
The median progression free survival (PFS) was 4 mo (95% CI: 2-NE).
The study of the population of Treg indicated that there were no significant differences in the groups depending on the effect (p = 0.71).
In one patient, the reduction of Treg cells was associated with increased TGF-β and IL-17 levels, whereas in other two pts the increase in Treg cells was associated with decreased TGF-β and IL-17 levels.
The endogenous levels of Epo did not show significant correlation with response to IFN-α immunotherapy.
In the patient subgroup with an initial value of MCH > 31 pg, the median PFS was not achieved, but in the subgroup with an initial value of MCH < 31 pg, the median PFS was 2 months (p = 0.032).
Conclusions.
In our study, we have described functional plasticity of Treg cells, which prevents them from being used as a prognostic marker.
The conversion of Treg cells into Th17 can serve as a basis for the development of a new specific immunotherapeutic method in oncology after confirmation in the experiment in vitro.
Given the small dataset, the results will need further validation.
American Psychological Association (APA)
Sayapina, M. S.& Bykovskaia, Svetlana N.. 2018. The Plasticity of CD4+CD25+FOXP3+CD127low T Cells in Patients with Metastatic Renal Cell Carcinoma in the Course of Interferon-Alpha Immunotherapy. Journal of Oncology،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1195857
Modern Language Association (MLA)
Sayapina, M. S.& Bykovskaia, Svetlana N.. The Plasticity of CD4+CD25+FOXP3+CD127low T Cells in Patients with Metastatic Renal Cell Carcinoma in the Course of Interferon-Alpha Immunotherapy. Journal of Oncology No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1195857
American Medical Association (AMA)
Sayapina, M. S.& Bykovskaia, Svetlana N.. The Plasticity of CD4+CD25+FOXP3+CD127low T Cells in Patients with Metastatic Renal Cell Carcinoma in the Course of Interferon-Alpha Immunotherapy. Journal of Oncology. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1195857
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195857