The Neuroprotective Effects of Brazilian Green Propolis on Neurodegenerative Damage in Human Neuronal SH-SY5Y Cells
Joint Authors
Meng, Jie
Ni, Junjun
Zhong, Xin
Wu, Shizheng
Zhu, Aiqin
Nakanishi, Hiroshi
Wu, Zhou
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-06
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Oxidative stress and synapse dysfunction are the major neurodegenerative damage correlated to cognitive impairment in Alzheimer’s disease (AD).
We have found that Brazilian green propolis (propolis) improves the cognitive functions of mild cognitive impairment patients living at high altitude; however, mechanism underlying the effects of propolis is unknown.
In the present study, we investigated the effects of propolis on oxidative stress, expression of brain-derived neurotrophic factor (BDNF), and activity-regulated cytoskeleton-associated protein (Arc), the critical factors of synapse efficacy, using human neuroblastoma SH-SY5Y cells.
Pretreatment with propolis significantly ameliorated the hydrogen peroxide- (H2O2-) induced cytotoxicity in SH-SY5Y cells.
Furthermore, propolis significantly reduced the H2O2-generated reactive oxygen species (ROS) derived from mitochondria and 8-oxo-2′-deoxyguanosine (8-oxo-dG, the DNA oxidative damage marker) but significantly reversed the fibrillar β-amyloid and IL-1β-impaired BDNF-induced Arc expression in SH-SY5Y cells.
Furthermore, propolis significantly upregulated BDNF mRNA expression in time- and dose-dependent manners.
In addition, propolis induced Arc mRNA and protein expression via phosphoinositide-3 kinase (PI3K).
These observations strongly suggest that propolis protects from the neurodegenerative damage in neurons through the properties of various antioxidants.
The present study provides a potential molecular mechanism of Brazilian green propolis in prevention of cognitive impairment in AD as well as aging.
American Psychological Association (APA)
Ni, Junjun& Wu, Zhou& Meng, Jie& Zhu, Aiqin& Zhong, Xin& Wu, Shizheng…[et al.]. 2017. The Neuroprotective Effects of Brazilian Green Propolis on Neurodegenerative Damage in Human Neuronal SH-SY5Y Cells. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1195858
Modern Language Association (MLA)
Ni, Junjun…[et al.]. The Neuroprotective Effects of Brazilian Green Propolis on Neurodegenerative Damage in Human Neuronal SH-SY5Y Cells. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1195858
American Medical Association (AMA)
Ni, Junjun& Wu, Zhou& Meng, Jie& Zhu, Aiqin& Zhong, Xin& Wu, Shizheng…[et al.]. The Neuroprotective Effects of Brazilian Green Propolis on Neurodegenerative Damage in Human Neuronal SH-SY5Y Cells. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1195858
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195858