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Mitochondrial Nucleoid: Shield and Switch of the Mitochondrial Genome
Joint Authors
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-06-07
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Mitochondria preserve very complex and distinctively unique machinery to maintain and express the content of mitochondrial DNA (mtDNA).
Similar to chromosomes, mtDNA is packaged into discrete mtDNA-protein complexes referred to as a nucleoid.
In addition to its role as a mtDNA shield, over 50 nucleoid-associated proteins play roles in mtDNA maintenance and gene expression through either temporary or permanent association with mtDNA or other nucleoid-associated proteins.
The number of mtDNA(s) contained within a single nucleoid is a fundamental question but remains a somewhat controversial issue.
Disturbance in nucleoid components and mutations in mtDNA were identified as significant in various diseases, including carcinogenesis.
Significant interest in the nucleoid structure and its regulation has been stimulated in relation to mitochondrial diseases, which encompass diseases in multicellular organisms and are associated with accumulation of numerous mutations in mtDNA.
In this review, mitochondrial nucleoid structure, nucleoid-associated proteins, and their regulatory roles in mitochondrial metabolism are briefly addressed to provide an overview of the emerging research field involving mitochondrial biology.
American Psychological Association (APA)
Lee, Sung Ryul& Han, Jin. 2017. Mitochondrial Nucleoid: Shield and Switch of the Mitochondrial Genome. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1195900
Modern Language Association (MLA)
Lee, Sung Ryul& Han, Jin. Mitochondrial Nucleoid: Shield and Switch of the Mitochondrial Genome. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1195900
American Medical Association (AMA)
Lee, Sung Ryul& Han, Jin. Mitochondrial Nucleoid: Shield and Switch of the Mitochondrial Genome. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1195900
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195900