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The Single Nucleotide Polymorphism PPARG2 Pro12Ala Affects Body Mass Index, Fat Mass, and Blood Pressure in Severely Obese Patients
Joint Authors
Aparecida da Silveira, Érika
Rosa, Lorena
Rodrigues, Ana Paula
Silva, Hugo Delleon da
Silveira-Lacerda, Elisângela de Paula
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-12-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Background.
The PPARG2 Pro12Ala (rs1801282) and IL6 -174G >C (rs1800795) have important function in body weight regulation and a potential role in obesity risk.
We aimed to investigate the association between PPARG2 Pro12Ala and IL6 -174G >C variants and the genotypes interaction with body composition, metabolic markers, food consumption, and physical activity in severely obese patients.
Methods.
150 severely obese patients (body mass index (BMI) ≥ 35 kg/m2) from Central Brazil were recruited.
Body composition, metabolic parameters, physical activity, and dietary intake were measured.
The genotype was determined by the qPCR TaqMan Assays System.
Multiple linear regression and multiple logistic regression models were fitted adjusting for confounders.
Results.
Ala carriers of the Pro12Ala polymorphism had higher adiposity measures (BMI: p=0.031, and fat mass: p=0.049) and systolic blood pressure (p=0.026) compared to Pro homozygotes.
We found no important associations between the -174G >C polymorphism and obesity phenotypes.
When genotypes were combined, individuals with genotypes ProAla + AlaAla and GC + CC presented higher BMI (p=0.029) and higher polyunsaturated fatty acids (PUFAs) consumption (p=0.045) compared to the ones with genotypes ProPro and GG, and individuals carriers of the PPARG2 Ala allele only (genotype ProAla + AlaAla and GG) had higher fat mass and systolic and diastolic blood pressure compared to the ones with genotypes ProPro and GG.
Conclusions.
Severely obese individuals carrying the Ala allele of the PPARG2 Pro12Ala polymorphism had higher measures of adiposity and blood pressure, while no important associations were found for the IL6 -174G >C polymorphism.
American Psychological Association (APA)
Rodrigues, Ana Paula& Rosa, Lorena& Silva, Hugo Delleon da& Silveira-Lacerda, Elisângela de Paula& Aparecida da Silveira, Érika. 2018. The Single Nucleotide Polymorphism PPARG2 Pro12Ala Affects Body Mass Index, Fat Mass, and Blood Pressure in Severely Obese Patients. Journal of Obesity،Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1195919
Modern Language Association (MLA)
Rodrigues, Ana Paula…[et al.]. The Single Nucleotide Polymorphism PPARG2 Pro12Ala Affects Body Mass Index, Fat Mass, and Blood Pressure in Severely Obese Patients. Journal of Obesity No. 2018 (2018), pp.1-9.
https://search.emarefa.net/detail/BIM-1195919
American Medical Association (AMA)
Rodrigues, Ana Paula& Rosa, Lorena& Silva, Hugo Delleon da& Silveira-Lacerda, Elisângela de Paula& Aparecida da Silveira, Érika. The Single Nucleotide Polymorphism PPARG2 Pro12Ala Affects Body Mass Index, Fat Mass, and Blood Pressure in Severely Obese Patients. Journal of Obesity. 2018. Vol. 2018, no. 2018, pp.1-9.
https://search.emarefa.net/detail/BIM-1195919
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195919