FTO rs9939609 Does Not Interact with Physical Exercise but Influences Basal Insulin Metabolism in Brazilian Overweight and Obese Adolescents

Joint Authors

Milano, Gerusa E.
Lopes, Wendell A.
Leite, Neiva
Nascimento, Gabrielle Araujo do
Furtado-Alle, Lupe
Teixeira, Mayza Dalcin
Silva, Larissa Rosa da
Pizzi, Juliana
Lopes, Maria de Fátima Aguiar
Titski, Ana Cláudia Kapp
Tureck, Luciane Viater
Souza, Ricardo L. R.

Source

Journal of Obesity

Issue

Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2018-04-26

Country of Publication

Egypt

No. of Pages

8

Main Subjects

Medicine

Abstract EN

Purpose.

The rs9939609 SNP (T > A) in FTO gene is associated with obesity and type 2 diabetes.

The present study aimed at verifying whether this SNP influenced biochemical outcomes of children and adolescents who are overweight/obese submitted to a program of physical exercise and also if there was influence on basal levels of these biochemical variables.

Methods.

The sample was composed by 432 children and adolescents grouped in three ways (obese, overweight, and normal weight); of these, 135 children and adoloescents who are obese and overweight were submitted to a physical exercise program for 12 weeks.

All were genotyped by TaqMan SNP genotyping assay.

Results.

The children and adolescents who are overweight/obese and carriers of AA genotype had higher levels of insulin (p=0.03) and HOMA (p=0.007) and lower levels of glucose (p=0.003), but the SNP did not modulate the response to physical exercise.

Conclusions.

In our study, the rs9939609 AA genotype was associated with parameters related to insulin metabolism but did not interact with physical exercise.

American Psychological Association (APA)

Nascimento, Gabrielle Araujo do& Leite, Neiva& Furtado-Alle, Lupe& Teixeira, Mayza Dalcin& Souza, Ricardo L. R.& Milano, Gerusa E.…[et al.]. 2018. FTO rs9939609 Does Not Interact with Physical Exercise but Influences Basal Insulin Metabolism in Brazilian Overweight and Obese Adolescents. Journal of Obesity،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1195928

Modern Language Association (MLA)

Nascimento, Gabrielle Araujo do…[et al.]. FTO rs9939609 Does Not Interact with Physical Exercise but Influences Basal Insulin Metabolism in Brazilian Overweight and Obese Adolescents. Journal of Obesity No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1195928

American Medical Association (AMA)

Nascimento, Gabrielle Araujo do& Leite, Neiva& Furtado-Alle, Lupe& Teixeira, Mayza Dalcin& Souza, Ricardo L. R.& Milano, Gerusa E.…[et al.]. FTO rs9939609 Does Not Interact with Physical Exercise but Influences Basal Insulin Metabolism in Brazilian Overweight and Obese Adolescents. Journal of Obesity. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1195928

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1195928