Roles and Mechanisms of Herbal Medicine for Diabetic Cardiomyopathy: Current Status and Perspective
Joint Authors
Liu, Yue
Chen, Keji
Tian, Jinfan
Liu, Yanfei
Zhao, Yingke
Lü, Shu-Zheng
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-24
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Diabetic cardiomyopathy is one of the major complications among patients with diabetes mellitus.
Diabetic cardiomyopathy (DCM) is featured by left ventricular hypertrophy, myocardial fibrosis, and damaged left ventricular systolic and diastolic functions.
The pathophysiological mechanisms include metabolic-altered substrate metabolism, dysfunction of microvascular, renin-angiotensin-aldosterone system (RAAS) activation, oxidative stress, cardiomyocyte apoptosis, mitochondrial dysfunction, and impaired Ca2+ handling.
An array of molecules and signaling pathways such as p38 mitogen-activated protein kinase (p38 MAPK), c-Jun N-terminal kinase (JNK), and extracellular-regulated protein kinases (ERK) take roles in the pathogenesis of DCM.
Currently, there was no remarkable effect in the treatment of DCM with application of single Western medicine.
The myocardial protection actions of herbs have been gearing much attention.
We present a review of the progress research of herbal medicine as a potential therapy for diabetic cardiomyopathy and the underlying mechanisms.
American Psychological Association (APA)
Tian, Jinfan& Zhao, Yingke& Liu, Yanfei& Liu, Yue& Chen, Keji& Lü, Shu-Zheng. 2017. Roles and Mechanisms of Herbal Medicine for Diabetic Cardiomyopathy: Current Status and Perspective. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1195954
Modern Language Association (MLA)
Tian, Jinfan…[et al.]. Roles and Mechanisms of Herbal Medicine for Diabetic Cardiomyopathy: Current Status and Perspective. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1195954
American Medical Association (AMA)
Tian, Jinfan& Zhao, Yingke& Liu, Yanfei& Liu, Yue& Chen, Keji& Lü, Shu-Zheng. Roles and Mechanisms of Herbal Medicine for Diabetic Cardiomyopathy: Current Status and Perspective. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1195954
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195954