Modulatory Mechanism of Polyphenols and Nrf2 Signaling Pathway in LPS Challenged Pregnancy Disorders
Joint Authors
Yin, Yulong
Tarique, Hussain
Tan, Bi’e
Rahu, Najma
Murtaza, Ghulam
Saleem, Muhammad
Liu, Gang-yu
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-23
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Early embryonic loss and adverse birth outcomes are the major reproductive disorders that affect both human and animals.
The LPS induces inflammation by interacting with robust cellular mechanism which was considered as a plethora of numerous reproductive disorders such as fetal resorption, preterm birth, teratogenicity, intrauterine growth restriction, abortion, neural tube defects, fetal demise, and skeletal development retardation.
LPS-triggered overproduction of free radicals leads to oxidative stress which mediates inflammation via stimulation of NF-κB and PPARγ transcription factors.
Flavonoids, which exist in copious amounts in nature, possess a wide array of functions; their supplementation during pregnancy activates Nrf2 signaling pathway which encounters pregnancy disorders.
It was further presumed that the development of strong antioxidant uterine environment during gestation can alleviate diseases which appear at adult stages.
The purpose of this review is to focus on modulatory properties of flavonoids on oxidative stress-mediated pregnancy insult and abnormal outcomes and role of Nrf2 activation in pregnancy disorders.
These findings would be helpful for providing new insights in ameliorating oxidative stress-induced pregnancy disorders.
American Psychological Association (APA)
Tarique, Hussain& Tan, Bi’e& Liu, Gang-yu& Murtaza, Ghulam& Rahu, Najma& Saleem, Muhammad…[et al.]. 2017. Modulatory Mechanism of Polyphenols and Nrf2 Signaling Pathway in LPS Challenged Pregnancy Disorders. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1195980
Modern Language Association (MLA)
Tarique, Hussain…[et al.]. Modulatory Mechanism of Polyphenols and Nrf2 Signaling Pathway in LPS Challenged Pregnancy Disorders. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-14.
https://search.emarefa.net/detail/BIM-1195980
American Medical Association (AMA)
Tarique, Hussain& Tan, Bi’e& Liu, Gang-yu& Murtaza, Ghulam& Rahu, Najma& Saleem, Muhammad…[et al.]. Modulatory Mechanism of Polyphenols and Nrf2 Signaling Pathway in LPS Challenged Pregnancy Disorders. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-14.
https://search.emarefa.net/detail/BIM-1195980
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195980