African Ancestry Gradient Is Associated with Lower Systemic F2-Isoprostane Levels
Joint Authors
Gower, Barbara A.
Il’yasova, Dora
Annor, Francis
Goodman, Michael
Thyagarajan, Bharat
Okosun, Ike S.
Doumatey, Ayo P.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-01-31
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Context.
Low levels of systemic F2-isoprostanes (F2-IsoP) increase the risk of diabetes and weight gain and were found in African Americans.
Low F2-IsoPs could reflect an unfavorable metabolic characteristic, namely, slow mitochondrial metabolism in individuals with African ancestry.
Objective.
To examine differences in plasma F2-IsoPs in three groups with a priori different proportion of African ancestry: non-Hispanic Whites (NHWs), US-born African Americans (AAs), and West African immigrants (WAI).
Design.
Cross-sectional study.
Setting.
Georgia residents recruited from church communities.
Participants.
218 males and females 25–74 years of age, who are self-identified as NHW (n=83), AA (n=56), or WAI (n=79).
Main Outcome Measure(s).
Plasma F2-IsoPs quantified by gas chromatography-mass spectrometry.
Results.
After adjustment for age, gender, obesity, and other comorbidities, WAI had lower levels of plasma F2-IsoP than AA (beta-coefficient = −9.8, p<0.001) and AA had lower levels than NHW (beta-coefficient = −30.3, p<0.001).
Similarly, among healthy nonobese participants, F2-IsoP levels were lowest among WAI, followed by AA, and the highest levels were among NHW.
Conclusion.
Plasma F2-IsoPs are inversely associated with African ancestry gradient.
Additional studies are required to test whether optimization of systemic F2-IsoP levels can serve as means to improve race-specific lifestyle and pharmacological intervention targeted to obesity prevention and treatment.
American Psychological Association (APA)
Annor, Francis& Goodman, Michael& Thyagarajan, Bharat& Okosun, Ike S.& Doumatey, Ayo P.& Gower, Barbara A.…[et al.]. 2017. African Ancestry Gradient Is Associated with Lower Systemic F2-Isoprostane Levels. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1195990
Modern Language Association (MLA)
Annor, Francis…[et al.]. African Ancestry Gradient Is Associated with Lower Systemic F2-Isoprostane Levels. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-7.
https://search.emarefa.net/detail/BIM-1195990
American Medical Association (AMA)
Annor, Francis& Goodman, Michael& Thyagarajan, Bharat& Okosun, Ike S.& Doumatey, Ayo P.& Gower, Barbara A.…[et al.]. African Ancestry Gradient Is Associated with Lower Systemic F2-Isoprostane Levels. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-7.
https://search.emarefa.net/detail/BIM-1195990
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195990