Chemical Composition and Pharmacological Effects of Geopropolis Produced by Melipona quadrifasciata anthidioides
Joint Authors
Carollo, Carlos Alexandre
Campos, Jaqueline Ferreira
Balestieri, José Benedito Perrella
de Picoli Souza, Kely
Santos, Edson Lucas dos
dos Santos, Cintia Miranda
dos Santos, Helder Freitas
Miranda Fernandes Estevinho, M. L.
Silva, Denise Brentan da
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-26
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Stingless bees produce geopropolis, which is popularly described for its medicinal properties, but for which few scientific studies have demonstrated pharmacological effects.
The objective of this study was to investigate the chemical composition of the geopropolis of Melipona quadrifasciata anthidioides and to evaluate its antioxidant, antimutagenic, anti-inflammatory, and antimicrobial activities.
The composition of the hydroethanolic extract of geopropolis (HEG) included di- and trigalloyl and phenylpropanyl heteroside derivatives, flavanones, diterpenes, and triterpenes.
HEG showed antioxidant action via the direct capture of free radicals and by inhibiting the levels of oxidative hemolysis and malondialdehyde in human erythrocytes under oxidative stress.
HEG also reduced the frequency of gene conversion and the number of mutant colonies of S.
cerevisiae.
The anti-inflammatory action of HEG was demonstrated by the inhibition of hyaluronidase enzyme activity.
In addition, HEG induced cell death in all evaluated gram-positive bacteria, gram-negative bacteria, and yeasts, including clinical isolates with antimicrobial drug resistance.
Collectively, these results demonstrate the potential of M.
q.
anthidioides geopropolis for the prevention and treatment of various diseases related to oxidative stress, mutagenesis, inflammatory processes, and microbial infections.
American Psychological Association (APA)
dos Santos, Cintia Miranda& Campos, Jaqueline Ferreira& dos Santos, Helder Freitas& Balestieri, José Benedito Perrella& Silva, Denise Brentan da& de Picoli Souza, Kely…[et al.]. 2017. Chemical Composition and Pharmacological Effects of Geopropolis Produced by Melipona quadrifasciata anthidioides. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1195992
Modern Language Association (MLA)
dos Santos, Cintia Miranda…[et al.]. Chemical Composition and Pharmacological Effects of Geopropolis Produced by Melipona quadrifasciata anthidioides. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1195992
American Medical Association (AMA)
dos Santos, Cintia Miranda& Campos, Jaqueline Ferreira& dos Santos, Helder Freitas& Balestieri, José Benedito Perrella& Silva, Denise Brentan da& de Picoli Souza, Kely…[et al.]. Chemical Composition and Pharmacological Effects of Geopropolis Produced by Melipona quadrifasciata anthidioides. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1195992
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1195992