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Obesity Is Associated with Early Onset of Gastrointestinal Cancers in California
Joint Authors
Eibl, Guido
Juo, Yen-Yi
Gibbons, Melinda A. Maggard
Dutson, Erik
Lin, Anne Y.
Yanagawa, Jane
Hines, O. Joe
Chen, Yijun
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-19
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Background.
Although it is well known that obesity is a risk factor for gastrointestinal (GI) cancer, it is not well established if obesity can cause earlier GI cancer onset.
Methods.
A cross-sectional study examining the linked 2004–2008 California Cancer Registry Patient Discharge Database was performed to evaluate the association between obesity and onset age among four gastrointestinal cancers, including esophageal, gastric, pancreatic, and colorectal cancers.
Regression models were constructed to adjust for other carcinogenic factors.
Results.
The diagnosis of obesity (BMI > 30) was associated with a reduction in diagnosis age across all four cancer types: 3.25 ± 0.53 years for gastric cancer, 4.56 ± 0.18 years for colorectal cancer, 4.73 ± 0.73 years for esophageal cancer, and 5.35 ± 0.72 for pancreatic cancer.
The diagnosis of morbid obesity (BMI > 40) was associated with a more pronounced reduction in the age of diagnosis: 5.48 ± 0.96 years for gastric cancer, 7.75 ± 0.30 years for colorectal cancer, 7.67 ± 1.26 years for esophageal cancer, and 8.19 ± 1.25 years for pancreatic cancer.
Both morbid obesity and obesity remained strongly associated with earlier cancer diagnosis for all four cancer types even after adjusting for other available cancer risk factors.
Conclusions.
The diagnosis of obesity, especially morbid obesity, was associated with a significantly earlier gastrointestinal cancer onset in California.
Further research with prospective cohort data may be required to establish the causal relationship between obesity and cancer onset age.
American Psychological Association (APA)
Juo, Yen-Yi& Gibbons, Melinda A. Maggard& Dutson, Erik& Lin, Anne Y.& Yanagawa, Jane& Hines, O. Joe…[et al.]. 2018. Obesity Is Associated with Early Onset of Gastrointestinal Cancers in California. Journal of Obesity،Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1196011
Modern Language Association (MLA)
Juo, Yen-Yi…[et al.]. Obesity Is Associated with Early Onset of Gastrointestinal Cancers in California. Journal of Obesity No. 2018 (2018), pp.1-6.
https://search.emarefa.net/detail/BIM-1196011
American Medical Association (AMA)
Juo, Yen-Yi& Gibbons, Melinda A. Maggard& Dutson, Erik& Lin, Anne Y.& Yanagawa, Jane& Hines, O. Joe…[et al.]. Obesity Is Associated with Early Onset of Gastrointestinal Cancers in California. Journal of Obesity. 2018. Vol. 2018, no. 2018, pp.1-6.
https://search.emarefa.net/detail/BIM-1196011
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196011