Adiposity Is a Key Correlate of Circulating Fibroblast Growth Factor-21 Levels in African Males with or without Type 2 Diabetes Mellitus
Joint Authors
Krook, Anna
Zierath, Juleen R.
Mashili, Fredirick L.
Ramaiya, Kaushik
Lutale, Janet
Francis, Filbert
Njelekela, Marina
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-09-12
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Fibroblast growth factor-21 is an endocrine regulator with therapeutic and diagnostic potential.
The levels and pattern of circulating FGF-21 have been described mainly in European and Asian populations.
Given its strong association with adiposity, and the reported ethnic variabilities in body composition, examining FGF-21 in an African population is crucial.
Methods.
We measured levels of circulating FGF-21 in 207 overweight and obese Tanzanian males with or without type 2 diabetes mellitus (T2DM), and using statistical approaches, we explored their relationship with anthropometric and biochemical parameters.
Results.
Consistent with previous reports from European and Asian populations, we found higher levels of FGF-21 in people with T2DM compared to those without the disease.
Based on statistical models, measures of adiposity explained up to 59% of the variability in FGF-21 levels in the circulation.
Conclusion.
Levels of circulating FGF-21 in overweight and obese African males are higher in T2DM and strongly correlate with measures of adiposity.
American Psychological Association (APA)
Mashili, Fredirick L.& Ramaiya, Kaushik& Lutale, Janet& Njelekela, Marina& Francis, Filbert& Zierath, Juleen R.…[et al.]. 2018. Adiposity Is a Key Correlate of Circulating Fibroblast Growth Factor-21 Levels in African Males with or without Type 2 Diabetes Mellitus. Journal of Obesity،Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1196025
Modern Language Association (MLA)
Mashili, Fredirick L.…[et al.]. Adiposity Is a Key Correlate of Circulating Fibroblast Growth Factor-21 Levels in African Males with or without Type 2 Diabetes Mellitus. Journal of Obesity No. 2018 (2018), pp.1-8.
https://search.emarefa.net/detail/BIM-1196025
American Medical Association (AMA)
Mashili, Fredirick L.& Ramaiya, Kaushik& Lutale, Janet& Njelekela, Marina& Francis, Filbert& Zierath, Juleen R.…[et al.]. Adiposity Is a Key Correlate of Circulating Fibroblast Growth Factor-21 Levels in African Males with or without Type 2 Diabetes Mellitus. Journal of Obesity. 2018. Vol. 2018, no. 2018, pp.1-8.
https://search.emarefa.net/detail/BIM-1196025
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196025