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Resveratrol-Enriched Rice Attenuates UVB-ROS-Induced Skin Aging via Downregulation of Inflammatory Cascades
Joint Authors
Kim, Sun Yeou
Subedi, Lalita
Lee, Taek Hwan
Wahedi, Hussain Mustatab
Baek, So-Hyeon
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-08-16
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
The skin is the outermost protective barrier between the internal and external environments in humans.
Chronic exposure to ultraviolet (UV) radiation is a major cause of skin aging.
UVB radiation penetrates the skin and induces ROS production that activates three major skin aging cascades: matrix metalloproteinase- (MMP-) 1-mediated aging; MAPK-AP-1/NF-κB-TNF-α/IL-6, iNOS, and COX-2-mediated inflammation-induced aging; and p53-Bax-cleaved caspase-3-cytochrome C-mediated apoptosis-induced aging.
These mechanisms are collectively responsible for the wrinkling and photoaging characteristic of UVB-induced skin aging.
There is an urgent requirement for a treatment that not only controls these pathways to prevent skin aging but also avoids the adverse effects often encountered when applying bioactive compounds in concentrated doses.
In this study, we investigated the efficacy of genetically modified normal edible rice (NR) that produces the antiaging compound resveratrol (R) as a treatment for skin aging.
This resveratrol-enriched rice (RR) overcomes the drawbacks of R and enhances its antiaging potential by controlling the abovementioned three major pathways of skin aging.
RR does not exhibit the toxicity of R alone and promisingly downregulates the pathways underlying UVB-ROS-induced skin aging.
These findings advocate the use of RR as a nutraceutical for antiaging purposes.
American Psychological Association (APA)
Subedi, Lalita& Lee, Taek Hwan& Wahedi, Hussain Mustatab& Baek, So-Hyeon& Kim, Sun Yeou. 2017. Resveratrol-Enriched Rice Attenuates UVB-ROS-Induced Skin Aging via Downregulation of Inflammatory Cascades. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1196066
Modern Language Association (MLA)
Subedi, Lalita…[et al.]. Resveratrol-Enriched Rice Attenuates UVB-ROS-Induced Skin Aging via Downregulation of Inflammatory Cascades. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-15.
https://search.emarefa.net/detail/BIM-1196066
American Medical Association (AMA)
Subedi, Lalita& Lee, Taek Hwan& Wahedi, Hussain Mustatab& Baek, So-Hyeon& Kim, Sun Yeou. Resveratrol-Enriched Rice Attenuates UVB-ROS-Induced Skin Aging via Downregulation of Inflammatory Cascades. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-15.
https://search.emarefa.net/detail/BIM-1196066
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196066