Astragaloside IV for Experimental Focal Cerebral Ischemia: Preclinical Evidence and Possible Mechanisms
Joint Authors
Xu, Meng-Bei
Zhou, Xiao-Li
Wang, Hui-Lin
Zhou, Qi-Hui
Zheng, Guo-qing
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-13, 13 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-02-20
Country of Publication
Egypt
No. of Pages
13
Main Subjects
Abstract EN
Astragaloside IV (AST-IV) is a principal component of Radix Astragali seu Hedysari (Huangqi) and exerts potential neuroprotection in experimental ischemic stroke.
Here, we systematically assessed the effectiveness and possible mechanisms of AST-IV for experimental acute ischemic stroke.
An electronic search in eight databases was conducted from inception to March 2016.
The study quality score was evaluated using the CAMARADES.
Rev Man 5.0 software was used for data analyses.
Thirteen studies with 244 animals were identified.
The study quality score of included studies ranged from 3/10 to 8/10.
Eleven studies showed significant effects of AST-IV for ameliorating the neurological function score (P<0.05); seven studies for reducing the infarct volume (P<0.05); and three or two studies for reducing the brain water content and Evans blue leakage (P<0.05), respectively, compared with the control.
The mechanisms of AST-IV for ischemic stroke are multiple such as antioxidative/nitration stress reaction, anti-inflammatory, and antiapoptosis.
In conclusion, the findings of present study indicated that AST-IV could improve neurological deficits and infarct volume and reduce the blood-brain barrier permeability in experimental cerebral ischemia despite some methodological flaws.
Thus, AST-IV exerted a possible neuroprotective effect during the cerebral ischemia/reperfusion injury largely through its antioxidant, anti-inflammatory, and antiapoptosis properties.
American Psychological Association (APA)
Wang, Hui-Lin& Zhou, Qi-Hui& Xu, Meng-Bei& Zhou, Xiao-Li& Zheng, Guo-qing. 2017. Astragaloside IV for Experimental Focal Cerebral Ischemia: Preclinical Evidence and Possible Mechanisms. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1196101
Modern Language Association (MLA)
Wang, Hui-Lin…[et al.]. Astragaloside IV for Experimental Focal Cerebral Ischemia: Preclinical Evidence and Possible Mechanisms. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-13.
https://search.emarefa.net/detail/BIM-1196101
American Medical Association (AMA)
Wang, Hui-Lin& Zhou, Qi-Hui& Xu, Meng-Bei& Zhou, Xiao-Li& Zheng, Guo-qing. Astragaloside IV for Experimental Focal Cerebral Ischemia: Preclinical Evidence and Possible Mechanisms. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-13.
https://search.emarefa.net/detail/BIM-1196101
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196101