Redox Regulation of Inflammatory Processes Is Enzymatically Controlled
Joint Authors
Bekeschus, Sander
Hanschmann, Eva-Maria
Lorenzen, Inken
Mullen, Lisa
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-23, 23 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-08
Country of Publication
Egypt
No. of Pages
23
Main Subjects
Abstract EN
Redox regulation depends on the enzymatically controlled production and decay of redox active molecules.
NADPH oxidases, superoxide dismutases, nitric oxide synthases, and others produce the redox active molecules superoxide, hydrogen peroxide, nitric oxide, and hydrogen sulfide.
These react with target proteins inducing spatiotemporal modifications of cysteine residues within different signaling cascades.
Thioredoxin family proteins are key regulators of the redox state of proteins.
They regulate the formation and removal of oxidative modifications by specific thiol reduction and oxidation.
All of these redox enzymes affect inflammatory processes and the innate and adaptive immune response.
Interestingly, this regulation involves different mechanisms in different biological compartments and specialized cell types.
The localization and activity of distinct proteins including, for instance, the transcription factor NFκB and the immune mediator HMGB1 are redox-regulated.
The transmembrane protein ADAM17 releases proinflammatory mediators, such as TNFα, and is itself regulated by a thiol switch.
Moreover, extracellular redox enzymes were shown to modulate the activity and migration behavior of various types of immune cells by acting as cytokines and/or chemokines.
Within this review article, we will address the concept of redox signaling and the functions of both redox enzymes and redox active molecules in innate and adaptive immune responses.
American Psychological Association (APA)
Lorenzen, Inken& Mullen, Lisa& Bekeschus, Sander& Hanschmann, Eva-Maria. 2017. Redox Regulation of Inflammatory Processes Is Enzymatically Controlled. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-23.
https://search.emarefa.net/detail/BIM-1196107
Modern Language Association (MLA)
Lorenzen, Inken…[et al.]. Redox Regulation of Inflammatory Processes Is Enzymatically Controlled. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-23.
https://search.emarefa.net/detail/BIM-1196107
American Medical Association (AMA)
Lorenzen, Inken& Mullen, Lisa& Bekeschus, Sander& Hanschmann, Eva-Maria. Redox Regulation of Inflammatory Processes Is Enzymatically Controlled. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-23.
https://search.emarefa.net/detail/BIM-1196107
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196107