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The Interrelation between Reactive Oxygen Species and Autophagy in Neurological Disorders
Joint Authors
Xiong, Xiaoxing
Gu, Lijuan
Mao, Shanping
Fang, Congcong
Smerin, Daniel
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-16, 16 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-12-17
Country of Publication
Egypt
No. of Pages
16
Main Subjects
Abstract EN
Neurological function deficits due to cerebral ischemia or neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD) have long been considered a thorny issue in clinical treatment.
Recovery after neurologic impairment is fairly limited, which poses a major threat to health and quality of life.
Accumulating evidences support that ROS and autophagy are both implicated in the onset and development of neurological disorders.
Notably, oxidative stress triggered by excess of ROS not only puts the brain in a vulnerable state but also enhances the virulence of other pathogenic factors, just like mitochondrial dysfunction, which is described as the culprit of nerve cell damage.
Nevertheless, autophagy is proposed as a subtle cellular defense mode against destructive stimulus by timely removal of damaged and cytotoxic substance.
Emerging evidence suggests that the interplay of ROS and autophagy may establish a determinant role in the modulation of neuronal homeostasis.
However, the underlying regulatory mechanisms are still largely unexplored.
This review sets out to afford an overview of the crosstalk between ROS and autophagy and discusses relevant molecular mechanisms in cerebral ischemia, AD, and PD, so as to provide new insights into promising therapeutic targets for the abovementioned neurological conditions.
American Psychological Association (APA)
Fang, Congcong& Gu, Lijuan& Smerin, Daniel& Mao, Shanping& Xiong, Xiaoxing. 2017. The Interrelation between Reactive Oxygen Species and Autophagy in Neurological Disorders. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1196119
Modern Language Association (MLA)
Fang, Congcong…[et al.]. The Interrelation between Reactive Oxygen Species and Autophagy in Neurological Disorders. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-16.
https://search.emarefa.net/detail/BIM-1196119
American Medical Association (AMA)
Fang, Congcong& Gu, Lijuan& Smerin, Daniel& Mao, Shanping& Xiong, Xiaoxing. The Interrelation between Reactive Oxygen Species and Autophagy in Neurological Disorders. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-16.
https://search.emarefa.net/detail/BIM-1196119
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196119