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Tear Ferning Test and Pathological Effects on Ocular Surface before and after Topical Cyclosporine in Vernal Keratoconjunctivitis Patients
Joint Authors
Lambiase, Alessandro
Sacchetti, Marta
Zicari, Anna Maria
Duse, Marzia
Bianchi, Guia
Del Regno, Paola
Nebbioso, Marcella
Source
Issue
Vol. 2018, Issue 2018 (31 Dec. 2018), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2018-10-14
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Background.
Vernal keratoconjunctivitis (VKC) is a rare ocular surface inflammatory disease that affects mainly boys in the first decade of life.
Clinical observations show that it generally regresses spontaneously with the onset of puberty, but therapeutic measures must be taken before then to control the course of the disease.
Purpose.To evaluate the role of the lacrimal mucous component in VKC patients and compare tear ferning test (TFT) modifications, MUC5AC levels in tears, and density of conjunctival goblet cells to clinical characteristics before and after treatment with cyclosporine A (CY) in eye drops.
Methods.
Forty-seven patients affected by VKC and 30 healthy subjects aged between 3 and 16 years of life were enrolled.
All individuals were submitted to complete eye examination and skin prick test (SPT) for the most common allergens.
Then, they were subjected to collection of the tears and to impression cytology to evaluate TFT, MUC5AC levels, and conjunctival goblet cell density, before and after treatment with CY in eye drops.
Results.
Comparing the VKC group vs.
the control group at baseline, a significant alteration in the degree of the ferns was found, indicating a pathological condition of the lacrimal mucous layer.
In addition, an increased number of goblet cells were observed in the patients.
The concentration of lacrimal secretory mucins (MUC5AC) did not show significant differences between the 2 groups.
Patients treated with CY have reported improvements of some signs and symptoms of disease activity, including TFT, and a tendency of conjunctival goblet cell density to normalise.
Conclusions.
The results obtained demonstrated for the first time a significant alteration of the lacrimal mucin component evaluated in the VKC group, and an improvement of the latter after CY therapy.
American Psychological Association (APA)
Nebbioso, Marcella& Sacchetti, Marta& Bianchi, Guia& Zicari, Anna Maria& Duse, Marzia& Del Regno, Paola…[et al.]. 2018. Tear Ferning Test and Pathological Effects on Ocular Surface before and after Topical Cyclosporine in Vernal Keratoconjunctivitis Patients. Journal of Ophthalmology،Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1196127
Modern Language Association (MLA)
Nebbioso, Marcella…[et al.]. Tear Ferning Test and Pathological Effects on Ocular Surface before and after Topical Cyclosporine in Vernal Keratoconjunctivitis Patients. Journal of Ophthalmology No. 2018 (2018), pp.1-11.
https://search.emarefa.net/detail/BIM-1196127
American Medical Association (AMA)
Nebbioso, Marcella& Sacchetti, Marta& Bianchi, Guia& Zicari, Anna Maria& Duse, Marzia& Del Regno, Paola…[et al.]. Tear Ferning Test and Pathological Effects on Ocular Surface before and after Topical Cyclosporine in Vernal Keratoconjunctivitis Patients. Journal of Ophthalmology. 2018. Vol. 2018, no. 2018, pp.1-11.
https://search.emarefa.net/detail/BIM-1196127
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196127