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Effect of Chronic Administration of Resveratrol on Cognitive Performance during Aging Process in Rats
Joint Authors
Brambila, Eduardo
Aguilar-Alonso, Patricia
Navarro-Cruz, Addí Rhode
Ochoa-Velasco, Carlos Enrique
Avila-Sosa, Raul
Ramírez y Ayala, R.
Pérez-Fernández, S.
Morales-Medina, J. C.
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2017, Issue 2017 (31 Dec. 2017), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2017-10-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The increase in the elderly population has generated concern to meet health demands.
The research efforts to elucidate the mechanisms of damage associated with aging have also been significantly increased, especially in order to avoid the reduction of the cognitive abilities in geriatric patients, resulting from the damage generated mainly at the level of the hippocampus during old age.
At present, many studies describe resveratrol as an antiaging component.
There are reports that it can activate the Sirt1 gene related to antiaging, emulating the effects obtained by caloric restriction in rodents.
The aim of the study was to evaluate the effect of chronic administration of resveratrol (10 mg/kg) on cognitive performance in behavioral tests after 8 months of treatment and on the preservation of cerebral integrity in the cytoarchitecture of regions CA1 and CA2.
Results showed that the cytoarchitecture of the CA1 and CA2 regions in the hippocampus retained their integrity over time in rats treated with resveratrol, and the behavioral test performed revealed that chronic resveratrol administration for 8 months showed improvements in cognitive performance.
The results indicate that resveratrol may exhibit therapeutic potential for age-related conditions.
American Psychological Association (APA)
Navarro-Cruz, Addí Rhode& Ramírez y Ayala, R.& Ochoa-Velasco, Carlos Enrique& Brambila, Eduardo& Avila-Sosa, Raul& Pérez-Fernández, S.…[et al.]. 2017. Effect of Chronic Administration of Resveratrol on Cognitive Performance during Aging Process in Rats. Oxidative Medicine and Cellular Longevity،Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1196132
Modern Language Association (MLA)
Navarro-Cruz, Addí Rhode…[et al.]. Effect of Chronic Administration of Resveratrol on Cognitive Performance during Aging Process in Rats. Oxidative Medicine and Cellular Longevity No. 2017 (2017), pp.1-8.
https://search.emarefa.net/detail/BIM-1196132
American Medical Association (AMA)
Navarro-Cruz, Addí Rhode& Ramírez y Ayala, R.& Ochoa-Velasco, Carlos Enrique& Brambila, Eduardo& Avila-Sosa, Raul& Pérez-Fernández, S.…[et al.]. Effect of Chronic Administration of Resveratrol on Cognitive Performance during Aging Process in Rats. Oxidative Medicine and Cellular Longevity. 2017. Vol. 2017, no. 2017, pp.1-8.
https://search.emarefa.net/detail/BIM-1196132
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1196132